Non-Progressive Leukoencephalopathy with Bilateral Temporal Cysts

Gomes, AL; Vieira, JP; Saldanha, J

http://hdl.handle.net/10400.17/2341

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Authors

Gomes, AL

Vieira, JP

Saldanha, J

Abstract(s)

We report two cases of a peculiar leukoencephalopathy with temporal cysts. Both patients have a non-progressive neurological disorder with mental retardation, microcephaly and sensorineural deafness although clinical differences between them may reflect a different aetiology. The metabolic disorders with white matter involvement and the recently described leukoencephalopathies (Van Der Knaap disease, 'vanishing white matter disease') were excluded based on clinical, biologic and imaging findings. Cytomegalovirus infection is a likely possibility in the first case although the magnetic resonance imaging picture is only partially similar to previously reported cases. Our patients are strikingly similar to the patients reported by Deonna et al. and Olivier et al. We discuss the clinical and imaging findings in our patients and the differential diagnosis considering the known disorders of the white matter in childhood.

Keywords

Central Nervous System Cysts/diagnosis Cerebral Cortex/pathology Cytomegalovirus Infections/congenital Cytomegalovirus Infections/diagnosis Demyelinating Diseases/diagnosis Diagnosis, Differential Dominance, Cerebral/physiology Intellectual Disability/diagnosis Magnetic Resonance Imaging Child Infant, Low Birth Weight Follow-Up Studies HDE NEU PED