Repository logo
 
Publication

Use of CPAP to Reduce Arterial Stiffness in Moderate-to-Severe Obstructive Sleep Apnoea, Without Excessive Daytime Sleepiness (STIFFSLEEP): an Observational Cohort Study Protocol

2016Journal article Open access
Simple item page
dc.contributor.authorMineiro, A
dc.contributor.authorMarques da Silva, P
dc.contributor.authorAlves, M
dc.contributor.authorVirella, D
dc.contributor.authorMarques Gomes, MJ
dc.contributor.authorCardoso, J
dc.date.accessioned2016-07-26T15:37:41Z
dc.date.available2016-07-26T15:37:41Z
dc.date.issued2016
dc.description.abstractINTRODUCTION: Sleepiness is a cardinal symptom in obstructive sleep apnoea (OSA) but most patients have unspecific symptoms. Arterial stiffness, evaluated by pulse wave velocity (PWV), is related to atherosclerosis and cardiovascular (CV) risk. Arterial stiffness was reported to be higher in patients with OSA, improving after treatment with continuous positive airway pressure (CPAP). This study aims to assess whether the same effect occurs in patients with OSA and without sleepiness. METHODS AND ANALYSIS: This observational study assesses the CV effect of CPAP therapy on a cohort of patients with moderate-to-severe OSA; the effect on the subcohorts of sleepy and non-sleepy patients will be compared. A systematic and consecutive sample of patients advised CPAP therapy will be recruited from a single outpatient sleep clinic (Centro Hospitalar de Lisboa Central-CHLC, Portugal). Eligible patients are male, younger than 65 years, with confirmed moderate-to-severe OSA and apnoea-hypopnea index (AHI) above 15/hour. Other sleep disorders, diabetes or any CV disease other than hypertension are exclusion criteria. Clinical evaluation at baseline includes Epworth Sleepiness Scale (ESS), and sleepiness is defined as ESS above 10. OSA will be confirmed by polygraphic study (cardiorespiratory, level 3). Participants are advised to undertake an assessment of carotid-femoral PWV (cf-PWV) and 24 hours evaluation of ambulatory blood pressure monitoring (ABPM), at baseline and after 4 months of CPAP therapy. Compliance and effectiveness of CPAP will be assessed. The main outcome is the variation of cf-PWV over time.pt_PT
dc.identifier.citationBMJ Open. 2016 Jul 12;6(7):e011385pt_PT
dc.identifier.doi10.1136/bmjopen-2016-011385pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2545
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBMJ Publishing Grouppt_PT
dc.subjectHSM PNEUpt_PT
dc.subjectHSM MEDpt_PT
dc.subjectBlood Pressurept_PT
dc.subjectCohort Studiespt_PT
dc.subjectBlood Pressure Monitoring, Ambulatorypt_PT
dc.subjectContinuous Positive Airway Pressure/adverse effectspt_PT
dc.subjectHypertension/etiologypt_PT
dc.subjectHypertension/physiopathology
dc.subjectHypertension/prevention & control
dc.subjectPatient Compliance
dc.subjectPortugal
dc.subjectPulse Wave Analysis
dc.subjectResearch Design
dc.subjectSleep
dc.subjectSleep Apnea, Obstructive/complications
dc.subjectSleep Apnea, Obstructive/therapy
dc.subjectVascular Stiffness
dc.subjectWakefulness
dc.titleUse of CPAP to Reduce Arterial Stiffness in Moderate-to-Severe Obstructive Sleep Apnoea, Without Excessive Daytime Sleepiness (STIFFSLEEP): an Observational Cohort Study Protocolpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue7pt_PT
oaire.citation.startPagee011385pt_PT
oaire.citation.titleBMJ Openpt_PT
oaire.citation.volume6pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
BMJ Open-2016.pdf
Size:
611.41 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

PNEU - Artigos
MED - Artigos