Repository logo
 
Publication

Decreasing Incidence and Changes in Serotype Distribution of Invasive Pneumococcal Disease in Persons Aged Under 18 Years Since Introduction of 10-Valent and 13-Valent Conjugate Vaccines in Portugal, July 2008 to June 2012

2014Journal article Open access
Simple item page
dc.contributor.authorAguiar, SI
dc.contributor.authorBrito, MJ
dc.contributor.authorHoracio, AN
dc.contributor.authorLopes, JP
dc.contributor.authorRamirez, M
dc.contributor.authorMelo-Cristino, J
dc.date.accessioned2016-02-18T13:33:15Z
dc.date.available2016-02-18T13:33:15Z
dc.date.issued2014
dc.description.abstractThe 10-valent pneumococcal conjugate vaccine (PCV10) became available in Portugal in mid-2009 and the 13-valent vaccine (PCV13) in early 2010. The incidence of invasive pneumococcal disease (IPD) in patients aged under 18 years decreased from 8.19 cases per 100,000 in 2008–09 to 4.52/100,000 in 2011–12. However, IPD incidence due to the serotypes included in the 7-valent conjugate vaccine (PCV7) in children aged under two years remained constant. This fall resulted from significant decreases in the number of cases due to: (i) the additional serotypes included in PCV10 and PCV13 (1, 5, 7F; from 37.6% to 20.6%), particularly serotype 1 in older children; and (ii) the additional serotypes included in PCV13 (3, 6A, 19A; from 31.6% to 16.2%), particularly serotype 19A in younger children. The decrease in serotype 19A before vaccination indicates that it was not triggered by PCV13 administration. The decrease of serotype 1 in all groups, concomitant with the introduction of PCV10, is also unlikely to have been triggered by vaccination, although PCVs may have intensified and supported these trends. PCV13 serotypes remain major causes of IPD, accounting for 63.2% of isolates recovered in Portugal in 2011–12, highlighting the potential role of enhanced vaccination in reducing paediatric IPD in Portugal.pt_PT
dc.identifier.citationEuro Surveill. 2014 Mar 27;19(12):20750.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2397
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherEurosurveillance Orgpt_PT
dc.subjectMicrobial Sensitivity Testspt_PT
dc.subjectPneumococcal Infections/epidemiologypt_PT
dc.subjectPneumococcal Infections/immunologypt_PT
dc.subjectPneumococcal Infections/prevention & controlpt_PT
dc.subjectPneumococcal Vaccines/immunologypt_PT
dc.subjectPopulation Surveillancept_PT
dc.subjectSerotypingpt_PT
dc.subjectStreptococcus pneumoniae/classificationpt_PT
dc.subjectStreptococcus pneumoniae/immunologypt_PT
dc.subjectStreptococcus pneumoniae/isolation & purificationpt_PT
dc.subjectVaccines, Conjugate/immunologypt_PT
dc.subjectAdolescentpt_PT
dc.subjectChildpt_PT
dc.subjectChild, Preschoolpt_PT
dc.subjectHDE INF PEDpt_PT
dc.titleDecreasing Incidence and Changes in Serotype Distribution of Invasive Pneumococcal Disease in Persons Aged Under 18 Years Since Introduction of 10-Valent and 13-Valent Conjugate Vaccines in Portugal, July 2008 to June 2012pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue12pt_PT
oaire.citation.startPage20750pt_PT
oaire.citation.volume19pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Euro Surveill. 2014_19_20750.pdf
Size:
329.07 KB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

INF PED - Artigos