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Preoperative Prognostic Nutritional Index Predicts Survival of Patients with Intrahepatic Cholangiocarcinoma After Curative Resection

2018-09Journal article Open access
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dc.contributor.authorAkgül, Ö
dc.contributor.authorBagante, F
dc.contributor.authorOlsen, G
dc.contributor.authorCloyd, JM
dc.contributor.authorWeiss, M
dc.contributor.authorMerath, K
dc.contributor.authorAlexandrescu, S
dc.contributor.authorPinto Marques, H
dc.contributor.authorAldrighetti, L
dc.contributor.authorMaithel, SK
dc.contributor.authorPulitano, C
dc.contributor.authorBauer, TW
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, GA
dc.contributor.authorSoubrane, O
dc.contributor.authorMartel, G
dc.contributor.authorKoerkamp, BG
dc.contributor.authorGuglielmi, A
dc.contributor.authorItaru, E
dc.contributor.authorPawlik, TM
dc.date.accessioned2020-08-05T16:49:18Z
dc.date.available2020-08-05T16:49:18Z
dc.date.issued2018-09
dc.description.abstractBackground: Intrahepatic cholangiocarcinoma (ICC) is an aggressive malignancy. We sought to examine the association between preoperative prognostic nutritional index (PNI) and long-term overall survival among patients with ICC who underwent curative-intent resection. Methods: Patients who underwent hepatectomy for ICC between 1990 and 2015 were identified using an international multi-institutional database. Clinic-pathological characteristics and long-term outcomes of patients with PNI ≥ 40 and <40 were compared using univariable and multivariable analyses. Results: Among 637 patients, 53 patients had PNI < 40 (8.3%) and 584 patients had PNI ≥ 40 (91.7%). While there was no difference between PNI groups with regard to tumor size (P = .87), patients with PNI < 40 were more likely to have multifocal disease (PNI < 40, n = 16, 30.2% vs PNI ≥ 40, n = 65, 11.1%; P < 0.001), poorly differentiated or undifferentiated ICC (PNI < 40, n = 13, 25.5% vs PNI ≥ 40, n = 75, 13.1%; P = 0.020) and T2/T3/T4 disease vs patients with PNI ≥ 40 (PNI < 40, n = 38, 71.7% vs PNI ≥ 40, n = 265, 45.4%; P < 0.001). Patients with PNI ≥ 40 had better OS vs patients with PNI < 40 (5-year OS: PNI ≥ 40: 47.5%, 95% CI, 42.2 to 52.6% vs PNI < 40: 24.6%, 95% CI, 12.1 to 39.6%; P < 0.001). On multivariable analysis, PNI < 40 remained associated with increase risk of death (HR, 1.71; 95% CI, 1.15 to 2.53; P = 0.008). Conclusion: A low preoperative PNI was associated with a more aggressive ICC phenotype. After controlling for these factors, PNI remained independently associated with a markedly worse prognosis.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Surg Oncol . 2018 Sep;118(3):422-430.pt_PT
dc.identifier.doi10.1002/jso.25140pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3482
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAgedpt_PT
dc.subjectBile Duct Neoplasmspt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHepatectomypt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPrognosispt_PT
dc.subjectSurvival Ratept_PT
dc.subjectNutrition Assessmentpt_PT
dc.subjectPreoperative Carept_PT
dc.subjectHCC CIRpt_PT
dc.titlePreoperative Prognostic Nutritional Index Predicts Survival of Patients with Intrahepatic Cholangiocarcinoma After Curative Resectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage430pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage422pt_PT
oaire.citation.titleJournal of Surgical Oncologypt_PT
oaire.citation.volume118pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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