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Association Between Ventilatory Settings and Development of Acute Respiratory Distress Syndrome in Mechanically Ventilated Patients Due to Brain Injury

2017Journal article Open access
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dc.contributor.authorTejerina, E
dc.contributor.authorPelosi, P
dc.contributor.authorMuriel, A
dc.contributor.authorPeñuelas, O
dc.contributor.authorSutherasan, Y
dc.contributor.authorFrutos-Vivar, F
dc.contributor.authorNin, N
dc.contributor.authorDavies, AR
dc.contributor.authorRios, F
dc.contributor.authorVioli, DA
dc.contributor.authorRaymondos, K
dc.contributor.authorHurtado, J
dc.contributor.authorGonzález, M
dc.contributor.authorDu, B
dc.contributor.authorAmin, P
dc.contributor.authorMaggiore, SM
dc.contributor.authorThille, AW
dc.contributor.authorSoares, MA
dc.contributor.authorJibaja, M
dc.contributor.authorVillagomez, AJ
dc.contributor.authorKuiper, MA
dc.contributor.authorKoh, Y
dc.contributor.authorMoreno, R
dc.contributor.authorZeggwagh, AA
dc.contributor.authorMatamis, D
dc.contributor.authorAnzueto, A
dc.contributor.authorFerguson, ND
dc.contributor.authorEsteban, A
dc.date.accessioned2018-01-31T16:31:46Z
dc.date.available2018-01-31T16:31:46Z
dc.date.issued2017
dc.description.abstractPURPOSE: In neurologically critically ill patients with mechanical ventilation (MV), the development of acute respiratory distress syndrome (ARDS) is a major contributor to morbidity and mortality, but the role of ventilatory management has been scarcely evaluated. We evaluate the association of tidal volume, level of PEEP and driving pressure with the development of ARDS in a population of patients with brain injury. MATERIALS AND METHODS: We performed a secondary analysis of a prospective, observational study on mechanical ventilation. RESULTS: We included 986 patients mechanically ventilated due to an acute brain injury (hemorrhagic stroke, ischemic stroke or brain trauma). Incidence of ARDS in this cohort was 3%. Multivariate analysis suggested that driving pressure could be associated with the development of ARDS (odds ratio for unit increment of driving pressure 1.12; confidence interval for 95%: 1.01 to 1.23) whereas we did not observe association for tidal volume (in ml per kg of predicted body weight) or level of PEEP. ARDS was associated with an increase in mortality, longer duration of mechanical ventilation, and longer ICU length of stay. CONCLUSIONS: In a cohort of brain-injured patients the development of ARDS was not common. Driving pressure was associated with the development of this disease.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Crit Care. 2017 Apr;38:341-345pt_PT
dc.identifier.doi10.1016/j.jcrc.2016.11.010pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2876
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectBrain Injuriespt_PT
dc.subjectCritical Illnesspt_PT
dc.subjectFemalept_PT
dc.subjectGlasgow Coma Scalept_PT
dc.subjectHumanspt_PT
dc.subjectIncidencept_PT
dc.subjectIntensive Care Unitspt_PT
dc.subjectLength of Staypt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMorbiditypt_PT
dc.subjectMortalitypt_PT
dc.subjectMultivariate Analysispt_PT
dc.subjectPressurept_PT
dc.subjectProspective Studiespt_PT
dc.subjectRespiration, Artificialpt_PT
dc.subjectRespiratory Distress Syndrome, Adultpt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTime Factorspt_PT
dc.subjectPositive-Pressure Respirationpt_PT
dc.subjectTidal Volumept_PT
dc.subjectHSJ UCIpt_PT
dc.titleAssociation Between Ventilatory Settings and Development of Acute Respiratory Distress Syndrome in Mechanically Ventilated Patients Due to Brain Injurypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage345pt_PT
oaire.citation.startPage341pt_PT
oaire.citation.titleJournal of Critical Carept_PT
oaire.citation.volume38pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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