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The Association Between Hepatitis B Virus Infection and Nonliver Malignancies in Persons Living with HIV: Results from the EuroSIDA Study

2021-07Journal article Open access
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dc.contributor.authorMocroft, A
dc.contributor.authorMiro, J
dc.contributor.authorWandeler, G
dc.contributor.authorLlibre, J
dc.contributor.authorBoyd, A
dc.contributor.authorvan Bremen, K
dc.contributor.authorBeniowski, M
dc.contributor.authorMikhalik, J
dc.contributor.authorCavassini, M
dc.contributor.authorMaltez, F
dc.contributor.authorDuvivier, C
dc.contributor.authorUberti Foppa, C
dc.contributor.authorKnysz, B
dc.contributor.authorBakowska, E
dc.contributor.authorKuzovatova, E
dc.contributor.authorDomingo, P
dc.contributor.authorZagalo, A
dc.contributor.authorViard, JP
dc.contributor.authorDegen, O
dc.contributor.authorMilinkovic, A
dc.contributor.authorBenfield, T
dc.contributor.authorPeters, L
dc.contributor.authorHarxhi, A
dc.contributor.authorLosso, M
dc.contributor.authorKundro, M
dc.contributor.authorSchmied, B
dc.contributor.authorZangerle, R
dc.contributor.authorKarpov, I
dc.contributor.authorVassilenko, A
dc.contributor.authorMitsura, V
dc.contributor.authorPaduto, D
dc.contributor.authorClumeck, N
dc.contributor.authorDe Wit, S
dc.contributor.authorDelforge, M
dc.contributor.authorFlorence, E
dc.contributor.authorVandekerckhove, L.
dc.contributor.authorHadziosmanovic, V
dc.contributor.authorBegovac, J
dc.contributor.authorMachala, L
dc.contributor.authorSedlacek, D
dc.contributor.authorKronborg, G
dc.contributor.authorGerstoft, J
dc.contributor.authorKatzenstein, T
dc.contributor.authorPedersen, C
dc.contributor.authorJohansen, I
dc.contributor.authorOstergaard, L
dc.contributor.authorWiese, L
dc.contributor.authorMoller, N
dc.contributor.authorNielsen, L
dc.contributor.authorZilmer, K
dc.contributor.authorSmidt, J
dc.contributor.authorAho, I
dc.contributor.authorLacombe, K
dc.contributor.authorPradier, C
dc.contributor.authorFontas, E
dc.contributor.authorRockstroh, J
dc.contributor.authorBehrens, G
dc.contributor.authorHoffmann, C
dc.contributor.authorStellbrink, H
dc.contributor.authorStefan, C
dc.contributor.authorBogner, J
dc.contributor.authorFätkenheuer, G
dc.contributor.authorChkhartishvili, N
dc.contributor.authorSambatakou, H
dc.contributor.authorAdamis, G
dc.contributor.authorPaissios, N
dc.contributor.authorSzlávik, J
dc.contributor.authorGottfredsson, M
dc.contributor.authorDevitt, E
dc.contributor.authorTau, L
dc.contributor.authorTurner, D
dc.contributor.authorBurke, M
dc.contributor.authorShahar, E
dc.contributor.authorWattad, L
dc.contributor.authorElinav, H
dc.contributor.authorHaouzi, M
dc.contributor.authorElbirt, D
dc.contributor.authorD’Arminio Monforte, A
dc.contributor.authorEsposito, R
dc.contributor.authorMazeu, I
dc.contributor.authorMussini, C
dc.contributor.authorMazzotta, F
dc.contributor.authorGabbuti, A
dc.contributor.authorLazzarin, A
dc.contributor.authorCastagna, A
dc.contributor.authorGianotti, N
dc.contributor.authorGalli, M
dc.contributor.authorRidolfo, A
dc.contributor.authorUzdaviniene, V
dc.contributor.authorMatulionyte, R
dc.contributor.authorStaub, T
dc.contributor.authorHemmer, R
dc.contributor.authorDragas, S
dc.contributor.authorStevanovic, M
dc.contributor.authorvd Valk, M
dc.contributor.authorTrajanovska, J
dc.contributor.authorReikvam, D
dc.contributor.authorMaeland, A
dc.contributor.authorBruun, J
dc.contributor.authorSzetela, B
dc.contributor.authorInglot, M
dc.contributor.authorFlisiak, R
dc.contributor.authorGrzeszczuk, A
dc.contributor.authorParczewski, M
dc.contributor.authorMaciejewska, K
dc.contributor.authorAksak‐Was, B
dc.contributor.authorMularska, E
dc.contributor.authorJablonowska, E
dc.contributor.authorKamerys, J
dc.contributor.authorWojcik, K
dc.contributor.authorMozer‐Lisewska, I
dc.contributor.authorRozplochowski, B
dc.contributor.authorMansinho, K
dc.contributor.authorRadoi, R
dc.contributor.authorOprea, C
dc.contributor.authorGusev, D
dc.contributor.authorTrofimova, T
dc.contributor.authorKhromova, I
dc.contributor.authorBorodulina, E
dc.contributor.authorRanin, J
dc.contributor.authorTomazic, J
dc.contributor.authorMiró, J
dc.contributor.authorLaguno, M
dc.contributor.authorMartinez, E
dc.contributor.authorGarcia, F
dc.contributor.authorBlanco, J
dc.contributor.authorMartinez‐Rebollar, M
dc.contributor.authorMallolas, J
dc.contributor.authorCallau, P
dc.contributor.authorRojas, J
dc.contributor.authorInciarta, A
dc.contributor.authorMoreno, S
dc.contributor.authordel Campo, S
dc.contributor.authorClotet, B
dc.contributor.authorJou, A
dc.contributor.authorParedes, R
dc.contributor.authorPuig, J
dc.contributor.authorSantos, J
dc.contributor.authorGutierrez, M
dc.contributor.authorMateo, G
dc.contributor.authorSambeat, M
dc.contributor.authorLaporte, J
dc.contributor.authorSvedhem, V
dc.contributor.authorThalme, A
dc.contributor.authorSönnerborg, A
dc.contributor.authorBrännström, J
dc.contributor.authorFlamholc, L
dc.contributor.authorKusejko, K
dc.contributor.authorBraun, D
dc.contributor.authorCalmy, A
dc.contributor.authorFurrer, H
dc.contributor.authorBattegay, M
dc.contributor.authorSchmid, P
dc.contributor.authorKuznetsova, A
dc.contributor.authorSluzhynska, M
dc.contributor.authorJohnson, A
dc.contributor.authorSimons, E
dc.contributor.authorEdwards, S
dc.contributor.authorPhillips, A
dc.contributor.authorJohnson, M
dc.contributor.authorOrkin, C
dc.contributor.authorWinston, A
dc.contributor.authorClarke, A
dc.contributor.authorLeen, C
dc.contributor.authorKarpov, I
dc.contributor.authorLosso, M
dc.contributor.authorLundgren, J
dc.contributor.authorRockstroh, J
dc.contributor.authorAho, I
dc.contributor.authorRasmussen, L
dc.contributor.authorSvedhem, V
dc.contributor.authorPradier, C
dc.contributor.authorChkhartishvili, N
dc.contributor.authorMatulionyte, R
dc.contributor.authorOprea, C
dc.contributor.authorKowalska, J
dc.contributor.authorBegovac, J
dc.contributor.authorMiró, J
dc.contributor.authorGuaraldi, G
dc.contributor.authorParedes, R
dc.contributor.authorParedes, R
dc.contributor.authorLarsen, J
dc.contributor.authorBojesen, A
dc.contributor.authorNeesgaard, B
dc.contributor.authorJaschinski, N
dc.contributor.authorFursa, O
dc.contributor.authorSather, M
dc.contributor.authorRaben, D
dc.contributor.authorHansen, E
dc.contributor.authorKristensen, D
dc.contributor.authorFischer, A
dc.contributor.authorJensen, S
dc.contributor.authorElsing., T
dc.contributor.authorPhillips, A
dc.contributor.authorReekie, J
dc.contributor.authorCozzi‐Lepri, A
dc.contributor.authorAmele, S
dc.contributor.authorPelchen‐Matthews, A
dc.contributor.authorRoen, A
dc.contributor.authorTusch, E
dc.contributor.authorBannister., W
dc.date.accessioned2023-08-02T14:52:45Z
dc.date.available2023-08-02T14:52:45Z
dc.date.issued2021-07
dc.description.abstractObjectives: The aim of this study was to assess the impact of hepatitis B virus (HBV) infection on non-liver malignancies in people living with HIV (PLWH). Methods: All persons aged ≥ 18 years with known hepatitis B virus (HBV) surface antigen (HBsAg) status after the latest of 1 January 2001 and enrolment in the EuroSIDA cohort (baseline) were included in the study; persons were categorized as HBV positive or negative using the latest HBsAg test and followed to their first diagnosis of nonliver malignancy or their last visit. Results: Of 17 485 PLWH included in the study, 1269 (7.2%) were HBV positive at baseline. During 151 766 person-years of follow-up (PYFU), there were 1298 nonliver malignancies, 1199 in those currently HBV negative [incidence rate (IR) 8.42/1000 PYFU; 95% confidence interval (CI) 7.94-8.90/1000 PYFU] and 99 in those HBV positive (IR 10.54/1000 PYFU; 95% CI 8.47-12.62/1000 PYFU). After adjustment for baseline confounders, there was a significantly increased incidence of nonliver malignancies in HBV-positive versus HBV-negative individuals [adjusted incidence rate ratio (aIRR) 1.23; 95% CI 1.00-1.51]. Compared to HBV-negative individuals, HBsAg-positive/HBV-DNA-positive individuals had significantly increased incidences of nonliver malignancies (aIRR 1.37; 95% CI 1.00-1.89) and NHL (aIRR 2.57; 95% CI 1.16-5.68). There was no significant association between HBV and lung or anal cancer. Conclusions: We found increased rates of nonliver malignancies in HBsAg-positive participants, the increases being most pronounced in those who were HBV DNA positive and for NHL. If confirmed, these results may have implications for increased cancer screening in HIV-positive subjects with chronic HBV infection.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHIV Med . 2022 Jul;23(6):585-598.pt_PT
dc.identifier.doi10.1111/hiv.13210pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4623
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHCC INFpt_PT
dc.subjectHumanspt_PT
dc.subjectDNA, Viralpt_PT
dc.subjectHIV Infections* / complicationspt_PT
dc.subjectHepatitis B Surface Antigenspt_PT
dc.subjectHepatitis B virus / geneticspt_PT
dc.subjectHepatitis B* / complicationspt_PT
dc.subjectHepatitis B* / epidemiologypt_PT
dc.subjectHepatitis B, Chronic* / complicationspt_PT
dc.subjectHepatitis B, Chronic* / epidemiologypt_PT
dc.subjectNeoplasms* / complicationspt_PT
dc.titleThe Association Between Hepatitis B Virus Infection and Nonliver Malignancies in Persons Living with HIV: Results from the EuroSIDA Studypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage598pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage585pt_PT
oaire.citation.titleHIV Medicinept_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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