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Tear Meniscus and Corneal Sub-basal Nerve Plexus Assessment in Primary Sjögren Syndrome and Sicca Syndrome Patients.

2019-02Text Open access
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dc.contributor.authorCardigos, Joana
dc.contributor.authorBarcelos, Filipe
dc.contributor.authorCarvalho, Helena
dc.contributor.authorHipólito, Diogo
dc.contributor.authorCrisóstomo, Sara
dc.contributor.authorVaz-Patto, José
dc.contributor.authorAlves, Nuno
dc.date.accessioned2025-04-17T11:11:28Z
dc.date.available2025-04-17T11:11:28Z
dc.date.issued2019-02
dc.description.abstractPurpose: To evaluate lower tear meniscus and corneal sub-basal nerve plexus in primary Sjögren's syndrome (pSS) and Sicca syndrome patients. Methods: Cross-sectional study of 116 patients with Sicca syndrome associated with pSS and not associated with Sjögren's syndrome (non-SS Sicca) and 20 normal control subjects. Tear meniscus height and area were measured using anterior segment optical coherence tomography; corneal sub-basal nerve plexus density, length, and tortuosity were evaluated using in vivo confocal microscopy. Data analysis was performed using IBM-SPSS Statistics 24.0. Results: Corneal sub-basal nerve plexus density and length were significantly lower, and tortuosity was significantly higher in pSS and non-SS Sicca groups than in normal control subjects (P < 0.001; P = 0.018, respectively). Corneal sub-basal nerve plexus presented a strong association with Schirmer test I and tear breakup time. Cutoff values of sub-basal nerve plexus density (36.5 nerve/mm) and length (12.5 mm/mm) presented 80.2% to 81.9% sensitivity and 85% specificity for detecting Sicca syndrome patients. No significant differences were found between the 3 groups regarding tear meniscus height and area. Conclusions: Corneal sub-basal nerve plexus in vivo confocal microscopy may be a useful tool in the assessment of dry eye disease in Sicca syndrome, complementing the information provided by the conventional modalities used in dry eye disease evaluation.eng
dc.identifier.citationCornea . 2019 Feb;38(2):221-228. doi: 10.1097/ICO.0000000000001800.
dc.identifier.doi10.1097/ICO.0000000000001800.
dc.identifier.pmid30379721
dc.identifier.urihttp://hdl.handle.net/10400.17/5082
dc.language.isoeng
dc.peerreviewedyes
dc.publisherWolters Kluwer Health, Inc.
dc.rights.uriN/A
dc.subjectHSAC OFT
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.subjectHumans
dc.subjectCase-Control Studies
dc.subjectCornea / innervation*
dc.subjectCross-Sectional Studies
dc.subjectDry Eye Syndromes / diagnosis*
dc.subjectDry Eye Syndromes / etiology
dc.subjectDry Eye Syndromes / physiopathology
dc.subjectMiddle Aged
dc.subjectMicroscopy
dc.subjectConfocal
dc.subjectSjogren's Syndrome / complications*
dc.subjectTears / metabolism*
dc.subjectTomography
dc.subjectOptical Coherence / methods
dc.titleTear Meniscus and Corneal Sub-basal Nerve Plexus Assessment in Primary Sjögren Syndrome and Sicca Syndrome Patients.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.endPage228
oaire.citation.issue2
oaire.citation.startPage221
oaire.citation.titleCornea
oaire.citation.volume38
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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