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Ocular Involvement in Systemic Lupus Erythematosus Patients: a Paradigm Shift Based on the Experience of a Tertiary Referral Center

2020-03Journal article Open access
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dc.contributor.authorDias-Santos, A
dc.contributor.authorFerreira, J
dc.contributor.authorPinheiro, S
dc.contributor.authorCunha, JP
dc.contributor.authorAlves, M
dc.contributor.authorPapoila, AL
dc.contributor.authorMoraes-Fontes, MF
dc.contributor.authorProença, R
dc.date.accessioned2021-11-23T15:12:01Z
dc.date.available2021-11-23T15:12:01Z
dc.date.issued2020-03
dc.description.abstractObjective: To evaluate ocular involvement in a cohort of systemic lupus erythematosus (SLE) patients of a tertiary referral center and to compare the results with the existing literature. Methods: Patients underwent a complete ophthalmological evaluation, including visual acuity, slit-lamp examination, fluorescein staining, Schirmer-I test, Goldmann applanation tonometry, fundoscopy, 10-2 automated threshold visual fields, fundus autofluorescence and spectral-domain optical coherence tomography to screen for hydroxychloroquine (HCQ) macular toxicity. Results: A total of 161 patients (16 men and 145 women) were enrolled in this study. The mean age was 47.6 years and the mean disease duration was 11.5 years. Fifty patients (31.1%) had at least one ocular manifestation of SLE. The most frequent manifestation was dry eye syndrome (12.4%), immediately followed by cataracts (11.2%) and HCQ macular toxicity (11.2%). Among patients with HCQ maculopathy, two presented with an atypical spectral-domain optical coherence tomography pattern. Five patients (3.1%) presented with glaucoma, two patients (1.2%) presented with SLE retinopathy while only one presented with lupus choroidopathy (0.6%). Conclusions: Compared with previous studies, we conclude there has been a significant reduction in disease-related ocular complications, particularly those associated with poor systemic disease control. On the other hand, drug and age-related complications are assuming a prominent role in the ophthalmic care of these patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationLupus. 2020 Mar;29(3):283-289.pt_PT
dc.identifier.doi10.1177/0961203320903080.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3915
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSagept_PT
dc.subjectCHLC OFTpt_PT
dc.subjectHSAC DAUTOIMpt_PT
dc.subjectHCC DAUTOIMpt_PT
dc.subjectCHLC CINVpt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectHumanspt_PT
dc.subjectAntirheumatic Agents / adverse effectspt_PT
dc.subjectDrug-Related Side Effects and Adverse Reactions / diagnosispt_PT
dc.subjectDrug-Related Side Effects and Adverse Reactions / etiologypt_PT
dc.subjectEye Diseases / diagnosispt_PT
dc.subjectEye Diseases / etiologypt_PT
dc.subjectHydroxychloroquine / adverse effectspt_PT
dc.subjectLupus Erythematosus, Systemic / complications*pt_PT
dc.subjectLupus Erythematosus, Systemic / diagnosispt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPrevalencept_PT
dc.subjectProspective Studiespt_PT
dc.subjectRetinal Diseases / chemically inducedpt_PT
dc.subjectRetinal Diseases / diagnosispt_PT
dc.subjectTertiary Care Centerspt_PT
dc.subjectTomography, Optical Coherencept_PT
dc.subjectVisual Acuitypt_PT
dc.titleOcular Involvement in Systemic Lupus Erythematosus Patients: a Paradigm Shift Based on the Experience of a Tertiary Referral Centerpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage289pt_PT
oaire.citation.startPage283pt_PT
oaire.citation.titleLupuspt_PT
oaire.citation.volume29pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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