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Association of Chronic Heart Failure with Mortality in Old Intensive Care Patients Suffering from Covid‐19

2022Journal article Open access
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dc.contributor.authorRomano Bruno, R
dc.contributor.authorWernly, B
dc.contributor.authorWolff, G
dc.contributor.authorFjølner, J
dc.contributor.authorArtigas, A
dc.contributor.authorBollen Pinto, B
dc.contributor.authorSchefold, J
dc.contributor.authorKindgen‐Milles, D
dc.contributor.authorBaldia, P
dc.contributor.authorKelm, M
dc.contributor.authorBeil, M
dc.contributor.authorSviri, S
dc.contributor.authorHeerden, P
dc.contributor.authorSzczeklik, W
dc.contributor.authorTopeli, A
dc.contributor.authorElhadi, M
dc.contributor.authorJoannidis, M
dc.contributor.authorOeyen, S
dc.contributor.authorKondili, E
dc.contributor.authorMarsh, B
dc.contributor.authorAndersen, F
dc.contributor.authorMoreno, R
dc.contributor.authorLeaver, S
dc.contributor.authorBoumendil, A
dc.contributor.authorDe Lange, D
dc.contributor.authorGuidet, B
dc.contributor.authorFlaatten, H
dc.contributor.authorJung, C
dc.date.accessioned2023-04-06T11:44:41Z
dc.date.available2023-04-06T11:44:41Z
dc.date.issued2022
dc.description.abstractAims: Chronic heart failure (CHF) is a major risk factor for mortality in coronavirus disease 2019 (COVID-19). This prospective international multicentre study investigates the role of pre-existing CHF on clinical outcomes of critically ill old (≥70 years) intensive care patients with COVID-19. Methods and results: Patients with pre-existing CHF were subclassified as having ischaemic or non-ischaemic cardiac disease; patients with a documented ejection fraction (EF) were subclassified according to heart failure EF: reduced (HFrEF, n = 132), mild (HFmrEF, n = 91), or preserved (HFpEF, n = 103). Associations of heart failure characteristics with the 30 day mortality were analysed in univariate and multivariate logistic regression analyses. Pre-existing CHF was reported in 566 of 3917 patients (14%). Patients with CHF were older, frailer, and had significantly higher SOFA scores on admission. CHF patients showed significantly higher crude 30 day mortality [60% vs. 48%, P < 0.001; odds ratio 1.87, 95% confidence interval (CI) 1.5-2.3] and 3 month mortality (69% vs. 56%, P < 0.001). After multivariate adjustment for confounders (SOFA, age, sex, and frailty), no independent association of CHF with mortality remained [adjusted odds ratio (aOR) 1.2, 95% CI 0.5-1.5; P = 0.137]. More patients suffered from pre-existing ischaemic than from non-ischaemic disease [233 vs. 328 patients (n = 5 unknown aetiology)]. There were no differences in baseline characteristics between ischaemic and non-ischaemic disease or between HFrEF, HFmrEF, and HFpEF. Crude 30 day mortality was significantly higher in HFrEF compared with HFpEF (64% vs. 48%, P = 0.042). EF as a continuous variable was not independently associated with 30 day mortality (aOR 0.98, 95% CI 0.9-1.0; P = 0.128). Conclusions: In critically ill older COVID-19 patients, pre-existing CHF was not independently associated with 30 day mortality.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationESC Heart Fail . 2022;9(3):1756-1765.pt_PT
dc.identifier.doi10.1002/ehf2.13854pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4473
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHSJ UCIpt_PT
dc.subjectCOVID-19* / complicationspt_PT
dc.subjectCritical Carept_PT
dc.subjectCOVID-19* / epidemiologypt_PT
dc.subjectChronic Diseasept_PT
dc.subjectHeart Failure* / complicationspt_PT
dc.subjectHeart Failure* / epidemiologypt_PT
dc.subjectHumanspt_PT
dc.subjectPrognosispt_PT
dc.subjectHospitalizationpt_PT
dc.subjectProspective Studiespt_PT
dc.subjectStroke Volumept_PT
dc.titleAssociation of Chronic Heart Failure with Mortality in Old Intensive Care Patients Suffering from Covid‐19pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1765pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1756pt_PT
oaire.citation.titleESC Heart Failurept_PT
oaire.citation.volume9pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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