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Major Determinants of Primary Non Function From Kidney Donation After Maastricht II Circulatory Death: a Single Center Experience

2024Journal article Open access
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dc.contributor.authorGaspar, A
dc.contributor.authorGama, M
dc.contributor.authorNobre de Jesus, G
dc.contributor.authorQuerido, S
dc.contributor.authorDamas, J
dc.contributor.authorOliveira, J
dc.contributor.authorNeves, M
dc.contributor.authorSantana, A
dc.contributor.authorRibeiro, JM
dc.date.accessioned2024-08-28T14:53:30Z
dc.date.available2024-08-28T14:53:30Z
dc.date.issued2024
dc.description.abstractPurpose: Organ shortage greatly limits treatment of patients with end-stage chronic kidney. Maastricht type 2 donation after circulatory death (DCD) has been shown to have similar results in long term outcomes in kidney transplantation, when compared with brain dead donation. Our main goal was to assess Maastricht type 2 DCD and evaluate factors that impact on early graft function. Methods: A retrospective study was conducted in an ECMO Referral Centre. All patients who received a kidney transplant from Maastricht type 2 DCD were included in study. Early graft function and short term outcomes were assessed. Results: From October 2017 to December 2022, 47 renal grafts were collected from 24 uDCD donors. Median warm ischemia time was 106 min (94-115), cannulation time was 10 min (8; 20) and duration of extracorporeal reperfusion (ANOR) was 180 min (126-214). Regarding early graft function, 25% had immediate graft function, 63.6% had delayed graft function and 11.4% had primary non-function (PNF). There was a correlation between cannulation time (p = 0.006) and ANOR with PNF (p = 0.016). Conclusions: Cannulation time and ANOR were the main factors that correlated with PNF. Better understanding of underlying mechanisms should be sought in future studies to reduce the incidence of PNF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJ Crit Care . 2024 Aug:82:154811pt_PT
dc.identifier.doi10.1016/j.jcrc.2024.154811pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/5016
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectHCC NEFpt_PT
dc.subjectHumanspt_PT
dc.subjectAdultpt_PT
dc.subjectMalept_PT
dc.subjectFemalept_PT
dc.subjectDelayed Graft Functionpt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectKidney Failure, Chronic / surgerypt_PT
dc.subjectKidney Failure, Chronic / therapypt_PT
dc.subjectKidney Transplantation*pt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectTissue Donors / supply & distributionpt_PT
dc.subjectTissue and Organ Procurement*pt_PT
dc.subjectWarm Ischemiapt_PT
dc.titleMajor Determinants of Primary Non Function From Kidney Donation After Maastricht II Circulatory Death: a Single Center Experiencept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.startPage154811pt_PT
oaire.citation.titleJournal of Critical Carept_PT
oaire.citation.volume82pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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