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Retinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathy

2016-11-01Journal article Open access
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dc.contributor.authorTavares Ferreira, J
dc.contributor.authorAlves, M
dc.contributor.authorDias-Santos, A
dc.contributor.authorCosta, L
dc.contributor.authorSantos, B
dc.contributor.authorCunha, JP
dc.contributor.authorPapoila, AL
dc.contributor.authorAbegão Pinto, L
dc.date.accessioned2017-10-24T14:48:31Z
dc.date.available2017-10-24T14:48:31Z
dc.date.issued2016-11-01
dc.description.abstractPURPOSE: To compare the thickness of all retinal layers between a nondiabetic group and diabetic patients without diabetic retinopathy (DR). METHODS: Cross-sectional study, in which all subjects underwent an ophthalmic examination including optical coherence tomography. After automatic retinal segmentation, each retinal layer thickness (eight separate layers and overall thickness) was calculated in all nine Early Treatment Diabetic Retinopathy Study (ETDRS) areas. The choroidal thickness (CT) also was measured at five locations. Generalized additive regression models were used to analyze the data. RESULTS: A total of 175 patients were recruited, 50 nondiabetic subjects and 125 diabetic patients without DR, stratified into three groups according to diabetes duration: group I (<5 years, n = 55), group II (5-10 years, n = 39), and group III (>10 years, n = 31). Overall, groups I and III of diabetic patients had a decrease in the photoreceptor layer (PR) thickness, when compared with the nondiabetic subjects in six ETDRS areas (P < 0.0007). Patients with more recent diagnosis (group I) had thinner PR than those with moderate duration (group II). Interestingly, patients with longer known disease (group III) had the thinnest PR values. There were no overall differences in the remaining retinal parameters. CONCLUSIONS: Retinal thickness profile is not linear throughout disease duration. Even in the absence of funduscopic disease, PR layer in diabetic patients seems to differ from nondiabetic subjects, thus suggesting that some form of neurodegeneration may take place before clinical signs of vascular problems arise.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInvest Ophthalmol Vis Sci. 2016 Nov 1;57(14):6455-6460pt_PT
dc.identifier.doi10.1167/iovs.16-20215pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2770
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.subjectAgedpt_PT
dc.subjectChoroidpt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectDiabetes Mellitus, Type 2pt_PT
dc.subjectDiabetic Retinopathypt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectOphthalmoscopypt_PT
dc.subjectRetinapt_PT
dc.subjectRetinal Degenerationpt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectTomography, Optical Coherencept_PT
dc.subjectCHLC OFTpt_PT
dc.titleRetinal Neurodegeneration in Diabetic Patients Without Diabetic Retinopathypt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage6460pt_PT
oaire.citation.issue14pt_PT
oaire.citation.startPage6455pt_PT
oaire.citation.titleInvestigative Ophthalmology & Visual Sciencept_PT
oaire.citation.volume57pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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