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Lymph Node Examination and Patterns of Nodal Metastasis Among Patients with Left- Versus Right-Sided Intrahepatic Cholangiocarcinoma After Major Curative-Intent Resection

2022Journal article Open access
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dc.contributor.authorZhang, XF
dc.contributor.authorXue, F
dc.contributor.authorWeiss, M
dc.contributor.authorPopescu, Irinel
dc.contributor.authorPinto Marques, H
dc.contributor.authorAldrighetti, L
dc.contributor.authorMaithel, S
dc.contributor.authorPulitano, C
dc.contributor.authorBauer, T
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, G
dc.contributor.authorCauchy, F
dc.contributor.authorMartel, G
dc.contributor.authorKoerkamp, B
dc.contributor.authorItaru, E
dc.contributor.authorLv, Y
dc.contributor.authorPawlik, T
dc.date.accessioned2024-08-22T13:44:47Z
dc.date.available2024-08-22T13:44:47Z
dc.date.issued2022
dc.description.abstractBackground: We sought to investigate whether the unique lateral patterns of lymphatic drainage impacted lymphadenectomy (LND), lymph node metastasis (LNM), and long-term survival of patients after curative hemi-hepatectomy for left- versus right-sided intrahepatic cholangiocarcinoma (ICC). Methods: Data on patients who underwent curative hemi-hepatectomy for left- or right-sided ICC were collected from 15 high-volume centers worldwide, as well as from the Surveillance, Epidemiology, and End Results (SEER) registry. Primary outcomes included overall survival (OS) and disease-free survival (DFS). Results: Among 697 patients identified from the multi-institutional database, patients who underwent hemi-hepatectomy for left-sided ICC (n = 363, 52.1%) were more likely to have an increased number of LND versus patients with right-sided ICC (n = 334, 47.9%) (median, left 5 versus right 3, p = 0.012), although the frequency (left 66.4% versus right 63.8%, p = 0.469) and station (beyond station no. 12, left 25.3% versus right 21.1%, p = 0.293) were similar. Consequently, left-sided ICC was associated with higher incidence of LNM (left 33.3% versus right 25.7%, p = 0.036), whereas the station and number of LNM were not different (both p > 0.1). There was no difference in OS (median, left 34.9 versus right 29.6 months, p = 0.130) or DFS (median, left 14.5 versus right 15.2 months, p = 0.771) among patients who underwent hemi-hepatectomy for left- versus right-sided ICC, which were also verified in the SEER dataset. LNM beyond station no. 12 was associated with even worse long-term survival versus LNM within station no. 12 among patients with either left- or right-sided ICC after curative-intent resection (all p < 0.05). Conclusions: The unique lateral patterns of lymphatic drainage were closely related to utilization of LND, as well as LNM of left- versus right-sided ICC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAnn Surg Oncol . 2023 Mar;30(3):1424-1433.pt_PT
dc.identifier.doi10.1245/s10434-022-12797-2pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/5000
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringerpt_PT
dc.subjectHCC CIRpt_PT
dc.subjectHumanspt_PT
dc.subjectBile Duct Neoplasms* / pathologypt_PT
dc.subjectPrognosispt_PT
dc.subjectBile Ducts, Intrahepatic / pathologypt_PT
dc.subjectCholangiocarcinoma* / pathologypt_PT
dc.subjectHepatectomypt_PT
dc.subjectLymph Node Excisionpt_PT
dc.subjectLymph Nodes / pathologypt_PT
dc.subjectLymph Nodes / surgerypt_PT
dc.subjectLymphatic Metastasis / pathologypt_PT
dc.titleLymph Node Examination and Patterns of Nodal Metastasis Among Patients with Left- Versus Right-Sided Intrahepatic Cholangiocarcinoma After Major Curative-Intent Resectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1433pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1424pt_PT
oaire.citation.titleAnnals of Surgical Oncologypt_PT
oaire.citation.volume30pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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