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Impact of Body Mass Index on Tumor Recurrence Among Patients Undergoing Curative - Intent Resection of Intrahepatic Cholangiocarcinoma - a Multi-institutional International Analysis

2019-06Journal article Open access
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dc.contributor.authorMerath, K
dc.contributor.authorMehta, R
dc.contributor.authorHyer, JM
dc.contributor.authorBagante, F
dc.contributor.authorSahara, K
dc.contributor.authorAlexandrescu, S
dc.contributor.authorPinto Marques, H
dc.contributor.authorAldrighetti, Luca
dc.contributor.authorMaithel, SK
dc.contributor.authorPulitano, C
dc.contributor.authorWeiss, MJ
dc.contributor.authorBauer, TW
dc.contributor.authorShen, F
dc.contributor.authorPoultsides, GA
dc.contributor.authorSoubrane, O
dc.contributor.authorMartel, G
dc.contributor.authorKoerkamp, BG
dc.contributor.authorGuglielmi, A
dc.contributor.authorItaru, E
dc.contributor.authorEjaz, A
dc.contributor.authorPawlik, TM
dc.date.accessioned2020-08-05T17:52:28Z
dc.date.available2020-08-05T17:52:28Z
dc.date.issued2019-06
dc.description.abstractBackground: The association between body mass index (BMI) and long-term outcomes of patients with ICC has not been well defined. We sought to define the presentation and oncologic outcomes of patients with ICC undergoing curative-intent resection, according to their BMI category. Methods: Patients who underwent resection of ICC were identified in a multi-institutional database. Patients were categorized as normal weight (BMI 18.5-24.9 kg/m2), overweight (BMI 25.0-29.9 kg/m2) and obese (BMI≥30 kg/m2) according to the World Health Organization (WHO) definition. Impact of clinico-pathological factors on recurrence-free survival (RFS) was assessed using Cox proportional hazards model among patients in the three BMI categories. Results: Among a total of 790 patients undergoing curative-intent resection of ICC in the analytic cohort, 399 (50.5%) had normal weight, 274 (34.7%) were overweight and 117 (14.8%) were obese. Caucasian patients were more likely to be obese (66.7%, n = 78) and overweight (47.1%, n = 129) compared with Asian (obese: 18.8%, n = 22; overweight: 46%, n = 126) and other races (obese: 14.5%, n = 17; overweight: 6.9%, n = 19)(p < 0.001). There were no differences in the presence of cirrhosis (10.9%, vs. 12.8%, vs. 12.9%), preoperative jaundice (8.6% vs. 9.5% vs. 12.0%), or levels of CA 19-9 (75, IQR 24.6-280 vs. 50.9, IQR 17.9-232 vs. 43, IQR 16.9-192.7) among the BMI groups (all p > 0.05). On multivariable analysis, increased BMI was an independent risk factor for tumor recurrence (OR 1.16, 95% CI 1.02-1.32, for every 5 unit increase). Conclusion: Increasing BMI was associated with incremental increases in the risk of recurrence following curative-intent resection of ICC. Future studies should aim to achieve a better understanding of BMI-related factors relative to prognosis of patients with ICC.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationEur J Surg Oncol. 2019 Jun;45(6):1084-1091.pt_PT
dc.identifier.doi10.1016/j.ejso.2019.03.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3486
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.subjectBile Duct Neoplasmspt_PT
dc.subjectCanadapt_PT
dc.subjectChinapt_PT
dc.subjectCholangiocarcinomapt_PT
dc.subjectDisease-Free Survivalpt_PT
dc.subjectEuropept_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHepatectomypt_PT
dc.subjectHumanspt_PT
dc.subjectIncidencept_PT
dc.subjectJapanpt_PT
dc.subjectMalept_PT
dc.subjectNeoplasm Recurrence, Localpt_PT
dc.subjectPrognosispt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectRisk Factorspt_PT
dc.subjectSurvival Ratept_PT
dc.subjectUnited Statespt_PT
dc.subjectBile Ducts, Intrahepaticpt_PT
dc.subjectBody Mass Indexpt_PT
dc.subjectHCC CIRpt_PT
dc.titleImpact of Body Mass Index on Tumor Recurrence Among Patients Undergoing Curative - Intent Resection of Intrahepatic Cholangiocarcinoma - a Multi-institutional International Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1091pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1084pt_PT
oaire.citation.titleEuropean Journal of Surgical Oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncologypt_PT
oaire.citation.volume45pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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