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Impact of Preoperative Chemotherapy Features on Patient Outcomes after Hepatectomy for Initially Unresectable Colorectal Cancer Liver Metastases: A LiverMetSurvey Analysis

2022-09Journal article Open access
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dc.contributor.authorInnominato, P
dc.contributor.authorCailliez, V
dc.contributor.authorAllard, MA
dc.contributor.authorLopez-Ben, S
dc.contributor.authorFerrero, A
dc.contributor.authorPinto Marques, H
dc.contributor.authorHubert, C
dc.contributor.authorGiuliante, F
dc.contributor.authorPereira, F
dc.contributor.authorCugat, E
dc.contributor.authorMirza, D
dc.contributor.authorCosta-Maia, J
dc.contributor.authorSerrablo, A
dc.contributor.authorLapointe, R
dc.contributor.authorDopazo, C
dc.contributor.authorTralhao, J
dc.contributor.authorKaiser, G
dc.contributor.authorChen, JS
dc.contributor.authorGarcia-Borobia, F
dc.contributor.authorRegimbeau, JM
dc.contributor.authorSkipenko, O
dc.contributor.authorLin, JK
dc.contributor.authorLaurent, C
dc.contributor.authorOpocher, E
dc.contributor.authorGoto, Y
dc.contributor.authorChibaudel, B
dc.contributor.authorde Gramont, A
dc.contributor.authorAdam, R
dc.date.accessioned2023-12-05T15:45:35Z
dc.date.available2023-12-05T15:45:35Z
dc.date.issued2022-09
dc.description.abstractBackground: Prognostic factors have been extensively reported after resection of colorectal liver metastases (CLM); however, specific analyses of the impact of preoperative systemic anticancer therapy (PO-SACT) features on outcomes is lacking. Methods: For this real-world evidence study, we used prospectively collected data within the international surgical LiverMetSurvey database from all patients with initially-irresectable CLM. The main outcome was Overall Survival (OS) after surgery. Disease-free (DFS) and hepatic-specific relapse-free survival (HS-RFS) were secondary outcomes. PO-SACT features included duration (cumulative number of cycles), choice of the cytotoxic backbone (oxaliplatin- or irinotecan-based), fluoropyrimidine (infusional or oral) and addition or not of targeted monoclonal antibodies (anti-EGFR or anti-VEGF). Results: A total of 2793 patients in the database had received PO-SACT for initially irresectable diseases. Short (<7 or <13 cycles in 1st or 2nd line) PO-SACT duration was independently associated with longer OS (HR: 0.85 p = 0.046), DFS (HR: 0.81; p = 0.016) and HS-RFS (HR: 0.80; p = 0.05). All other PO-SACT features yielded basically comparable results. Conclusions: In this international cohort, provided that PO-SACT allowed conversion to resectability in initially irresectable CLM, surgery performed as soon as technically feasible resulted in the best outcomes. When resection was achieved, our findings indicate that the choice of PO-SACT regimen had a marginal if any, impact on outcomes.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationCancers (Basel) . 2022 Sep 5;14(17):4340.pt_PT
dc.identifier.doi10.3390/cancers14174340pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4757
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.subjectHCC CIRpt_PT
dc.subjectLiverMetSurveypt_PT
dc.subjectColorectal Cancerpt_PT
dc.subjectDownsizingpt_PT
dc.subjectHepatectomypt_PT
dc.subjectIrresectable Hepatic Metastasespt_PT
dc.subjectLiver Metastasespt_PT
dc.subjectLiver Resectionpt_PT
dc.subjectNeo-Adjuvant Chemotherapypt_PT
dc.subjectOnco-Surgical Approachpt_PT
dc.subjectPreoperative Chemotherapypt_PT
dc.subjectReal-World Evidencept_PT
dc.titleImpact of Preoperative Chemotherapy Features on Patient Outcomes after Hepatectomy for Initially Unresectable Colorectal Cancer Liver Metastases: A LiverMetSurvey Analysispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue17pt_PT
oaire.citation.startPage4340pt_PT
oaire.citation.titleCancerspt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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