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Immunological Reconstitution Inflammatory Syndrome and Thrombotic Microangiopathy: Severe Complications in a Child With Acquired Immunodeficiency Syndrome

2019Journal article Open access
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dc.contributor.authorRocha, AP
dc.contributor.authorMilheiro Silva, T
dc.contributor.authorFrancisco, T
dc.contributor.authorNeves, C
dc.contributor.authorBrites, V
dc.contributor.authorCandeias, F
dc.date.accessioned2020-05-22T13:52:40Z
dc.date.available2020-05-22T13:52:40Z
dc.date.issued2019
dc.description.abstractSome patients with human immunodeficiency virus (HIV) infection deteriorate shortly after starting highly active antiretroviral therapy (HAART), the so-called immunological reconstitution inflammatory syndrome (IRIS).1 Although having a spontaneous resolution in many instances, it can be fatal.1 Worse prognosis is seen in younger children, severe immunosuppression and central nervous system IRIS, or infections with specific agents, namely, Criptococcus.2 Hemophagocytic lymphohistiocytosis (HLH) has also been described in children with HIV infection, in the context of an immunological system dysregulation.3 Thrombotic microangiopathy (TMA) became rare with the introduction of HAART, being mostly associated with advanced disease.4 HIV-associated TMA has specific clinical aspects as well as a worse prognosis than idiopathic or congenital TMA.4-9 The authors present the case of a 10-month-old boy with advanced HIV infection who developed IRIS complicated with HLH and TMA during the course of his treatment.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Pediatr (Phila) . 2019 Aug;58(9):1022-1026pt_PT
dc.identifier.doi10.1177/0009922819852984pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3466
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSAGE Publicationspt_PT
dc.subjectAcquired Immunodeficiency Syndromept_PT
dc.subjectAnti-Bacterial Agentspt_PT
dc.subjectAntiretroviral Therapy, Highly Activept_PT
dc.subjectDiagnosis, Differentialpt_PT
dc.subjectFatal Outcomept_PT
dc.subjectHumanspt_PT
dc.subjectImmune Reconstitution Inflammatory Syndromept_PT
dc.subjectImmunoglobulinspt_PT
dc.subjectInfantpt_PT
dc.subjectLymphohistiocytosis, Hemophagocyticpt_PT
dc.subjectMalept_PT
dc.subjectMethylprednisolonept_PT
dc.subjectThrombotic Microangiopathiespt_PT
dc.subjectHDE PEDpt_PT
dc.titleImmunological Reconstitution Inflammatory Syndrome and Thrombotic Microangiopathy: Severe Complications in a Child With Acquired Immunodeficiency Syndromept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1026pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1022pt_PT
oaire.citation.titleClinical pediatricspt_PT
oaire.citation.volume58pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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