Browsing by Author "Correia, S"
Now showing 1 - 5 of 5
Results Per Page
Sort Options
- Annular Lichen Planus in Association with Crohn DiseasePublication . Serrão, V; Organ, V; Pereira, L; Vale, E; Correia, SBACKGROUND: Lichen planus is an idiopathic inflammatory disease of the skin and mucous membranes. Although the etiology is not established, it has been associated with autoimmune diseases, viral infections, drugs and dental restoration materials. However, the association with inflammatory bowel disease has been very rarely reported in the literature. CASE REPORT: A 19-year-old female patient presented with annular lesions on her upper body and limbs, with a sharply defined border and non-atrophic skin in the center. The lesions were hyperpigmented and had been stable for over one year. The histopathology confirmed the diagnosis of annular lichen planus. She had weight loss, occasional diarrhea, and a severe anemia. The investigation of these symptoms led to the diagnosis of Crohn disease and a sickle cell trait. Therapy with systemic corticosteroids and mesalazine controlled the intestinal disease, with concomitant improvement of the skin lesions. CONCLUSIONS: As lichen planus can be associated with other immunological disorders, the association with inflammatory bowel disease should be considered in the evaluation of the patient.
- Diversidade e inclusão no CHULC, sabia que… na consulta de pedopsiquiatria no HDE existem grupos terapêuticos de pais e crianças?...Publication . Gomes, F; Santos, I; Martinho, S; Correia, S; Barca, C
- Doentes Covid-19 Traqueotomizados num Hospital Terciário: Resultados a Longo Prazo na Voz, Deglutição e Via AéreaPublication . Oliveira, M; Infante Velada, T; Dorozhko, I; Moreira, I; Chantre, T; Correia, S; Eliseu, A; Sousa, HA COVID-19 resultou num aumento de doentes traqueotomizados sob ventilação mecânica prolongada, cujas consequências na voz, deglutição e via aérea alta são pouco conhecidas, pelo que foi objetivo deste trabalho estudá-las. Foram considerados 37 doentes com COVID-19, internados numa Unidade de Cuidados Intensivos, traqueotomizados e descanulados entre março de 2020 e novembro de 2021. Foram incluídos no estudo 14 doentes, todos eles submetidos a entrevista com aplicação de inquéritos e 8 sujeitos também a endoscopia flexível. A média de idades foi de 49 anos e o racio masculino: feminino de 11:3. O tempo médio de entubação até à traqueotomia foi de 24 dias e até à descanulação de 51. 29% relataram alterações da deglutição, 14% da voz e 29% sintomas indicativos de refluxo faringolaríngeo. 62% das endoscopias apresentavam alterações. Os resultados preliminares mostram elevada incidência de lesões laríngeas, mas são necessários estudos a longo prazo, incluindo em doentes com COVID-19 não traqueotomizados.
- Fertility Care Provided by a Public Health Hospital to Viral-Infected Couples: A Case-Control StudyPublication . Figueiredo, S; Correia, S; Pinto, G; Simões, TObjective: To evaluate the results of ART (clinical pregnancies and baby home rates) in couples infected with HBV, HCV, HIV or mixed in a Referral center. Patients: The study is a retrospective case-control study comprising 1587 cycles/1064 couples in the control group and 237 cycles/164 couples in the infected group, submitted to in vitro fertilization, intracytoplasmic sperm injection and embryo transfer. Two branches from the infected group were created: the HIV subgroup, comprising couples with one or both partners infected with HIV-1 (84 cycles/67 couples), and the HCV subgroup, including at least one partner infected with HCV (45 cycles/29 couples). Results: The infected group presented higher infertility duration (P < 0.001) and so did the HCV subgroup (P < 0.001). Tubal infertility was increased in the infected group (P < 0.001), and in the HIV (P < 0.001) and HCV (P = 0.01) subgroups. Oocytes and oocytes in metaphase II numbers were lower in the infected group, but not in the HIV and HCV subgroups. Clinical pregnancy rate was lower in the infected group (25.74%) when compared to the control (34.66%), probably due to the contribution of HCV individuals (17.78%), but not of HIV (28.57%). Baby home rate was lower in the infected group (21.52%) relative to the control group (28.42%), but no differences were found in the HIV (27.38%) and HCV (15.56%) subgroups. Conclusions: Despite the low clinical pregnancy rate in the HCV subgroup, baby home rates did not change from control. These data seem promising for couples with viral infections who wish to conceive.
- Immune and Spermatogenesis-Related Loci are Involved in the Development of Extreme Patterns of Male InfertilityPublication . Cerván-Martín, M; Tüttelmann, F; Lopes, AM; Bossini-Castillo, L; Rivera-Egea, R; Garrido, N; Lujan, S; Romeu, G; Santos-Ribeiro, S; Castilla, JA; Carmen Gonzalvo, M; Clavero, A; Maldonado, V; Vicente, FJ; González-Muñoz, S; Guzmán-Jiménez, A; Burgos, M; Jiménez, R; Pacheco, A; González, C; Gómez, S; Amorós, D; Aguilar, J; Quintana, F; Calhaz-Jorge, C; Aguiar, A; Nunes, J; Sousa, S; Pereira, I; Pinto, MG; Correia, S; Sánchez-Curbelo, J; López-Rodrigo, O; Martín, J; Pereira-Caetano, I; Marques, PI; Carvalho, F; Barros, A; Gromoll, J; Bassas, L; Seixas, S; Gonçalves, J; Larriba, S; Kliesch, S; Palomino-Morales, RJ; Carmona, FDWe conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven million genetic variants were analysed in 1,274 SPGF cases and 1,951 unaffected controls from two independent European cohorts. Two genomic regions were associated with the most severe histological pattern of SPGF, defined by Sertoli cell-only (SCO) phenotype, namely the MHC class II gene HLA-DRB1 (rs1136759, P = 1.32E-08, OR = 1.80) and an upstream locus of VRK1 (rs115054029, P = 4.24E-08, OR = 3.14), which encodes a protein kinase involved in the regulation of spermatogenesis. The SCO-associated rs1136759 allele (G) determines a serine in the position 13 of the HLA-DRβ1 molecule located in the antigen-binding pocket. Overall, our data support the notion of unexplained SPGF as a complex trait influenced by common variation in the genome, with the SCO phenotype likely representing an immune-mediated condition.