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Browsing by Author "Gomez, AB"

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  • Invasive Bacterial Infections in Children With Sickle Cell Disease: 2014–2019
    Publication . Gaschignard, J; Koehl, B; Rees, DC; Rincón-López, E; Vanderfaeillie, A; Pascault, A; Allali, S; Cela, E; Odièvre, MH; Hau, I; Oliveira, M; Guillaumat, C; Brousse, V; de Montalembert, M; Navarro Gómez, ML; Beldjoudi, N; Bardon-Cancho, EJ; Epalza, C; Benkerrou, M; Gaschignard, J; Koehl, B; Pascault, A; Brousse, V; Allali, S; de Montalembert, M; Odièvre, MH; Hau, I; Guillaumat, C; Blais, S; Runel-Belliard, C; Pellegrino, B; Malric, A; Guitton, C; Gouraud, F; Petras, M; Bensaid, P; Basmaci, R; Eyssette-Guereau, S; Pham, LL; Bardon-Cancho, EJ; Cela, E; Gómez, ML; Rincon-Lopez, E; Ruiz-Llobet, A; Adan, R; Puyo, PV; Recasens, V; Epalza, C; Perez-Alonso, V; Torrent, M; Gomez, AB; Vázquez, A; Rodríguez, RP; Alfaridi, H; Almaghrabi, R; Hoyoux, M; Vanderfaeillie, A; Ferreira, T; Rees, D
    Background: Children with sickle cell disease (SCD) are at a high risk of invasive bacterial infections (IBI). Universal penicillin prophylaxis and vaccination, especially against Streptococcus pneumoniae, have deeply changed its epidemiology. Analysis of IBI in children with SCD in a post-13-valent pneumococcal vaccine era is limited. Methods: Twenty-eight pediatric hospitals from 5 European countries retrospectively collected IBI episodes in SCD children aged 1 month to 18 years between 2014 and 2019. IBI was defined as a positive bacterial culture or polymerase chain reaction from a normally sterile fluid: blood, cerebrospinal, joint, or pleural fluid and deep surgical specimen. Results: We recorded 169 IBI episodes. Salmonella spp. was the main isolated bacteria (n = 44, 26%), followed by Streptococcus pneumonia (Sp; n = 31, 18%) and Staphylococcus aureus (n = 20, 12%). Salmonella prevailed in osteoarticular infections and in primary bacteremia (45% and 23% of episodes, respectively) and Sp in meningitis and acute chest syndrome (88% and 50%, respectively). All Sp IBI occurred in children ≤10 years old, including 35% in children 5 to 10 years old. Twenty-seven (17%) children had complications of infection and 3 died: 2 because of Sp, and 1 because of Salmonella. The main risk factors for a severe IBI were a previous IBI and pneumococcal infection (17 Sp/51 cases). Conclusions: In a post-13-valent pneumococcal vaccine era, Salmonella was the leading cause of bacteremia in IBI in children with SCD in Europe. Sp came second, was isolated in children ≤10 years old, and was more likely to cause severe and fatal cases.
    2023Journal article Open access Show more