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Browsing by Author "Koppelman, GH"

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  • ARIA 2016: Care pathways implementing emerging technologies for predictive medicine in rhinitis and asthma across the life cycle
    Publication . Bousquet, J; Hellings, PW; Agache, I; Bedbrook, A; Bachert, C; Bergmann, KC; Bewick, M; Bindslev-Jensen, C; Bosnic-Anticevitch, S; Bucca, C; Caimmi, DP; Camargos, PAM; Canonica, G W; Casale, T; Chavannes, NH; Cruz, AA; De Carlo, G; Dahl, R; Demoly, P; Devillier, P; Fonseca, J; Fokkens, WJ; Guldemond, NA; Haahtela, T; Illario, M; Just, J; Keil, T; Klimek, L; Kuna, P; Larenas-Linnemann, D; Morais-Almeida, M; Mullol, J; Murray, R; Naclerio, R; O'Hehir, RE; Papadopoulos, NG; Pawankar, R; Potter, P; Ryan, D; Samolinski, B; Schunemann, HJ; Sheikh, A; Simons, FER; Stellato, C; Todo-Bom, A; Tomazic, PV; Valiulis, A; Valovirta, E; Ventura, MT; Wickman, M; Young, I; Yorgancioglu, A; Zuberbier, T; Aberer, W; Akdis, CA; Akdis, M; Annesi-Maesano, I; Ankri, J; Ansotegui, IJ; Anto, JM; Arnavielhe, S; Asarnoj, A; Arshad, H; Avolio, F; Baiardini, I; Barbara, C; Barbagallo, M; Bateman, D; Beghé, B; Bel, EH; Bennoor, KS; Benson, M; Białoszewski, AZ; Bieber, T; Bjermer, L; Blain, H; Blasi, F; Boner, L; Bonini, M; Bonini, S; Bosse, I; Bouchard, J; Boulet, LP; Bourret, R; Bousquet, PJ; Braido, F; Briggs, AH; Brightling, CE; Brozek, J; Buhl, R; Bunu, C; Burte, E; Bush, A; Caballero-Fonseca, F; Calderon, MA; Camuzat, T; Cardona, V; Carreiro-Martins, P; Carriazo, AM; Carlsen, K H; Carr, W; Cepeda Sarabia, AM; Cesari, M; Chatzi, L; Chiron, R; Chivato, T; Chkhartishvili, E; Chuchalin, AG; Chung, KF; Ciprandi, G; Correia de Sousa, J; Cox, L; Crooks, G; Custovic, A; Dahlen, SE; Darsow, U; Dedeu, T; Deleanu, D; Denburg, JA; De Vries, G; Didier, A; Dinh-Xuan, AT; Dokic, D; Douagui, H; Dray, G; Dubakiene, R; Durham, SR; Du Toit, G; Dykewicz, MS; Eklund, P; El-Gamal, Y; Ellers, E; Emuzyte, R; Farrell, J; Fink Wagner, A; Fiocchi, A; Fletcher, M; Forastiere, F; Gaga, M; Gamkrelidze, A; Gemicioğlu, B; Gereda, J E; van Wick, RG; González Diaz, S; Grisle, I; Grouse, L; Gutter, Z; Guzmán, MA; Hellquist-Dahl, B; Heinrich, J; Horak, F; Hourihane, JOB; Humbert, M; Hyland, M; Iaccarino, G; Jares, EJ; Jeandel, C; Johnston, SL; Joos, G; Jonquet, O; Jung, KS; Jutel, M; Kaidashev, I; Khaitov, M; Kalayci, O; Kalyoncu, A F; Kardas, P; Keith, PK; Kerkhof, M; Kerstjens, HAM; Khaltaev, N; Kogevinas, M; Kolek, V; Koppelman, GH; Kowalski, ML; Kuitunen, M; Kull, I; Kvedariene, V; Lambrecht, B; Lau, S; Laune, D; Le, LTT; Lieberman, P; Lipworth, B; Li, J; Lodrup Carlsen, KC; Louis, R; Lupinek, C; MacNee, W; Magar, Y; Magnan, A; Mahboub, B; Maier, D; Majer, I; Malva, J; Manning, P; De Manuel Keenoy, E; Marshall, GD; Masjedi, MR; Mathieu-Dupas, E; Maurer, M; Mavale-Manuel, S; Melén, E; Melo-Gomes, E; Meltzer, EO; Mercier, J; Merk, H; Miculinic, N; Mihaltan, F; Milenkovic, B; Millot-Keurinck, J; Mohammad, Y; Momas, I; Mösges, R; Muraro, A; Namazova-Baranova, L; Nadif, R; Neffen, H; Nekam, K; Nieto, A; Niggemann, B; Nogueira-Silva, L; Nogues, M; Nyembue, TD; Ohta, K; Okamoto, Y; Okubo, K; Olive-Elias, M; Ouedraogo, S; Paggiaro, P; Pali-Schöll, I; Palkonen, S; Panzner, P; Papi, A; Park, HS; Passalacqua, G; Pedersen, S; Pereira, AM; Pfaar, O; Picard, R; Pigearias, B; Pin, I; Plavec, D; Pohl, W; Popov, TA; Portejoie, F; Postma, D; Poulsen, LK; Price, D; Rabe, KF; Raciborski, F; Roberts, G; Robalo-Cordeiro, C; Rodenas, F; Rodriguez-Mañas, L; Rolland, C; Roman Rodriguez, M; Romano, A; Rosado-Pinto, J; Rosario, N; Rottem, M; Sanchez-Borges, M; Sastre-Dominguez, J; Scadding, GK; Scichilone, N; Schmid-Grendelmeier, P; Serrano, E; Shields, M; Siroux, V; Sisul, JC; Skrindo, I; Smit, HA; Solé, D; Sooronbaev, T; Spranger, O; Stelmach, R; Sterk, PJ; Strandberg, T; Sunyer, J; Thijs, C; Triggiani, M; Valenta, R; Valero, A; van Eerd, M; van Ganse, E; van Hague, M; Vandenplas, O; Varona, LL; Vellas, B; Vezzani, G; Vazankari, T; Viegi, G; Vontetsianos, T; Wagenmann, M; Walker, S; Wang, DY; Wahn, U; Werfel, T; Whalley, B; Williams, DM; Williams, S; Wilson, N; Wright, J; Yawn, BP; Yiallouros, PK; Yusuf, OM; Zaidi, A; Zar, HJ; Zernotti, ME; Zhang, L; Zhong, N; Zidarn, M
    The Allergic Rhinitis and its Impact on Asthma (ARIA) initiative commenced during a World Health Organization workshop in 1999. The initial goals were (1) to propose a new allergic rhinitis classification, (2) to promote the concept of multi-morbidity in asthma and rhinitis and (3) to develop guidelines with all stakeholders that could be used globally for all countries and populations. ARIA-disseminated and implemented in over 70 countries globally-is now focusing on the implementation of emerging technologies for individualized and predictive medicine. MASK [MACVIA (Contre les Maladies Chroniques pour un Vieillissement Actif)-ARIA Sentinel NetworK] uses mobile technology to develop care pathways for the management of rhinitis and asthma by a multi-disciplinary group and by patients themselves. An app (Android and iOS) is available in 20 countries and 15 languages. It uses a visual analogue scale to assess symptom control and work productivity as well as a clinical decision support system. It is associated with an inter-operable tablet for physicians and other health care professionals. The scaling up strategy uses the recommendations of the European Innovation Partnership on Active and Healthy Ageing. The aim of the novel ARIA approach is to provide an active and healthy life to rhinitis sufferers, whatever their age, sex or socio-economic status, in order to reduce health and social inequalities incurred by the disease.
    2016Journal article Open access Show more
  • Rhinitis Associated with Asthma is Distinct from Rhinitis Alone: The ARIA‐MeDALL Hypothesis
    Publication . Bousquet, J; Melén, E; Haahtela, T; Koppelman, GH; Togias, A; Valenta, R; Akdis, CA; Czarlewski, W; Rothenberg, M; Valiulis, A; Wickman, M; Akdis, M; Aguilar, D; Bedbrook, A; Bindslev‐Jensen, C; Bosnic‐Anticevich, S; Boulet, LP; Brightling, CE; Brussino, L; Burte, E; Bustamante, M; Canonica, GW; Cecchi, L; Celedon, JC; Chaves Loureiro, C; Costa, E; Cruz, AA; Erhola, M; Gemicioglu, B; Fokkens, WJ; Garcia‐Aymerich, J; Guerra, S; Heinrich, J; Ivancevich, JC; Keil, T; Klimek, L; Kuna, P; Kupczyk, M; Kvedariene, V; Larenas‐Linnemann, DE; Lemonnier, N; Lodrup Carlsen, KC; Louis, R; Makela, M; Makris, M; Maurer, M; Momas, I; Morais‐Almeida, M; Mullol, J.; Naclerio, RN; Nadeau, K; Nadif, R; Niedoszytko, M; Okamoto, Y; Ollert, M; Papadopoulos, NG; Passalacqua, G; Patella, V; Pawankar, R; Pham‐Thi, N; Pfaar, O; Regateiro, FS; Ring, J; Rouadi, PW; Samolinski, B; Sastre, J; Savouré, M; Scichilone, N; Shamji, MH; Sheikh, A; Siroux, V; Sousa‐Pinto, B; Standl, M; Sunyer, J; Taborda‐Barata, L; Toppila‐Salmi, S; Torres, MJ; Tsiligianni, I; Valovirta, E; Vandenplas, O; Ventura, MT; Weiss, S; Yorgancioglu, A; Zhang, L; Abdul Latiff, AH; Aberer, W; Agache, I; Al‐Ahmad, M; Alobid, I; Ansotegui, IJ; Arshad, SH; Asayag, E; Barbara, C; Baharudin, A; Battur, L; Bennoor, KS; Berghea, EC; Bergmann, KC; Bernstein, D; Bewick, M; Blain, H; Bonini, M; Braido, F; Buhl, R; Bumbacea, RS; Bush, A; Calderon, M; Calvo‐Gil, M; Camargos, P; Caraballo, L; Cardona, V; Carr, W; Carreiro‐Martins, P; Casale, T; Cepeda Sarabia, AM; Chandrasekharan, R; Charpin, D; Chen, YZ; Cherrez‐Ojeda, I; Chivato, T; Chkhartishvili, E; Christoff, G; Chu, DK; Cingi, C; Correia de Sousa, J; Corrigan, C; Custovic, A; D’Amato, G; Del Giacco, S; De Blay, F; Devillier, P; Didier, A; do Ceu Teixeira, M; Dokic, D; Douagui, H; Doulaptsi, M; Durham, S; Dykewicz, M; Eiwegger, T; El‐Sayed, ZA; Emuzyte, R; Fiocchi, A; Fyhrquist, N; Gomez, RM; Gotua, M; Guzman, MA; Hagemann, J; Hamamah, S; Halken, S; Halpin, DMG; Hofmann, M; Hossny, E; Hrubiško, M; Irani, C; Ispayeva, Z; Jares, E; Jartti, T; Jassem, E; Julge, K; Just, J; Jutel, M; Kaidashev, I; Kalayci, O; Kalyoncu, AF; Kardas, P; Kirenga, B; Kraxner, H; Kull, I; Kulus, M; La Grutta, S; Lau, S; Le Tuyet Thi, L; Levin, M; Lipworth, B; Lourenço, O; Mahboub, B; Martinez‐Infante, E; Matricardi, P; Miculinic, N; Migueres, N; Mihaltan, F; Mohammad, Y; Moniuszko, M; Montefort, S; Neffen, H; Nekam, K; Nunes, E; Nyembue Tshipukane, D; O’Hehir, R; Ogulur, I; Ohta, K; Okubo, K; Ouedraogo, S; Olze, H; Pali‐Schöll, I; Palomares, O; Palosuo, K; Panaitescu, C; Panzner, P; Park, HS; Pitsios, C; Plavec, D; Popov, TA; Puggioni, F; Quirce, S; Recto, M; Repka‐Ramirez, MS; Robalo Cordeiro, C; Roche, N; Rodriguez‐Gonzalez, M; Romantowski, J; Rosario Filho, N; Rottem, M; Sagara, H; Serpa, FS; Sayah, Z; Scheire, S; Schmid‐Grendelmeier, P; Sisul, JC; Sole, D; Soto‐Martinez, M; Sova, M; Sperl, A; Spranger, O; Stelmach, R; Suppli Ulrik, C; Thomas, M; To, T; Todo‐Bom, A; Tomazic, PV; Urrutia‐Pereira, M; Valentin‐Rostan, M; Van Ganse, E; van Hage, M; Vasankari, T; Vichyanond, P; Viegi, G; Wallace, D; Wang, DY; Williams, S; Worm, M; Yiallouros, P; Yusuf, O; Zaitoun, F; Zernotti, M; Zidarn, M; Zuberbier, J; Fonseca, JA; Zuberbier, T; Anto, JM
    Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.
    2023Journal article Open access Show more