Browsing by Author "Marques, P"
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- Aggressive Pituitary Lesion with a Remarkably High Ki-67Publication . Marques, P; Mafra, M; Calado, C; Martins, A; Monteiro, J; Leite, VOs raros tumores pituitários agressivos são chamados carcinomas quando são detectadas metástases, sejam sistêmicas e/ou em sistema nervoso central. Alguns casos estão associados com superprodução de hormônio, mas a maioria é diagnosticada em função dos sintomas locais. Essas neoplasias são geralmente refratárias aos tratamentos atuais. Uma mulher com 51 anos de idade apresentou dor de cabeça de início súbito, paralisia de braço esquerdo e hipoestesia facial esquerda. A tomografia e a ressonância magnética revelaram um tumor pituitário invadindo os seios esfenoidal e cavernoso esquerdos. Os dados laboratoriais excluíram hipersecreção hormonal. A paciente foi submetida à cirurgia transesfenoidal, e os achados histológicos mostraram uma neoplasia com Ki-67 estimado em 75%. As imagens excluíram tanto um tumor oculto primário quanto disseminação sistêmica ou do sistema nervoso central. Três semanas após a cirurgia, a condição neurológica apresentou piora com início de ataxia, ptose bilateral, oftalmoplegia e aumento do tamanho da lesão, levando à intervenção cirúrgica por craniotomia, seguida por apenas algumas sessões de radioterapia devido à progressão grave da doença. A paciente veio a óbito depois de quase dois meses das manifestações iniciais. O caso ilustra a agressividade de algumas lesões pituitárias, a eficácia limitada das modalidades atuais de tratamento, como a cirurgia ou a radioterapia, e as limitações da classificação atual de tumores pituitários. Até onde sabemos, esse caso corresponde a uma das neoplasias pituitárias mais agressivas descritas até hoje, com um nível muito alto de Ki-67 (75%) e sobrevida curta (2 meses). O nível de Ki-67 pode ser de valor prognóstico em tumores pituitários. A classificação da Organização Mundial da Saúde (OMS) para tumores pituitários deveria ser revisitada.
- Diplopia, Convergent Strabismus, and Eye Abduction Palsy in a 12-Year-Old Boy with Autoimmune ThyroiditisPublication . Marques, P; Jacinto, S; Pinto, MC; Limbert, C; Lopes, LPseudotumor cerebri (PTC) is defined by clinical criteria of increased intracranial pressure, elevated intracranial pressure with normal cerebrospinal fluid (CSF) composition, and exclusion of other causes such tumors, vascular abnormalities, or infections. The association of PTC with levothyroxine (LT4) has been reported. A 12-year-old boy has been followed up for autoimmune thyroiditis under LT4. Family history was irrelevant for endocrine or autoimmune diseases. A TSH level of 4.43 μUI/mL (0.39-3.10) motivated a LT4 adjustment from 75 to 88 μg/day. Five weeks later, he developed horizontal diplopia, convergent strabismus with left eye abduction palsy, and papilledema. Laboratorial evaluation revealed elevated free thyroxine level (1.05 ng/dL [0.65-1.01]) and low TSH, without other alterations. Lumbar puncture was performed and CSF opening pressure was 24 cm H2O with normal composition. Blood and CSF cultures were sterile. Brain MRI was normal. LT4 was temporarily discontinued and progressive improvement was observed, with a normal fundoscopy at day 10 and reversion of diplopia one month later. LT4 was restarted at lower dose and gradually titrated. The boy is currently asymptomatic. This case discloses the potential role of LT4 in inducing PTC. Despite its rarity and unclear association, PTC must be seen as a potential complication of LT4, after excluding all other intracranial hypertension causes.
- Efficacy and Safety of Novel Left Ventricular Pacing Leads: 1-Year Analysis of the NAVIGATOR TrialPublication . Martinez, JG; De Sousa, J; Dompnier, A; Oliveira, M; Israel, C; Teijeira, E; Rubin, JM; Sebag, F; Martino, M; Michel, Y; Marques, PObjectives: Assess safety and performance of novel quadripolar preshaped left ventricular (LV) leads: NAVIGO 4LV 2D ('S shaped') and NAVIGO 4LV ARC ('U shaped'). Methods: Patients indicated for cardiac resynchronisation therapy were enrolled in a multicentre, prospective, controlled study (NAVIGATOR, NCT03279484). Patients were implanted with either a NAVIGO 4LV 2D or ARC lead, and assessed at 10 weeks, 6, 12 and 24 months post-implant. Co-primary safety and performance endpoints were assessed at 10 weeks. Safety endpoint was the patients' rate free from lead-related complications. Performance endpoint was the rate of patients with successful lead performance, defined as LV pacing threshold ≤2.5 V at 0.5 ms on at least one pacing vector, and the absence of phrenic nerve stimulation at the final programmed configuration. Lead-related complications and electrical parameters were monitored throughout study. Results: A NAVIGO 4LV lead was successfully implanted in 211 out of 217 patients (97.2%). The safety endpoint was met, with 100% and 96.1% of patients free from complications for NAVIGO 4LV 2D and ARC, respectively. The performance endpoint was met with 98.1% and 98.9% of patients with a successful lead performance for NAVIGO 4LV 2D and ARC, respectively. Over 12 months, the global complication-free rate for both leads was 97.1% (95% CI: 93.71% to 98.70%), with a mean pacing capture threshold of 1.23 V±0.73 V and a mean impedance of 951 Ω±300.1 Ω. Conclusion: A high implantation success rate and low complication rate was reported for the novel NAVIGO 4LV 2D and ARC leads, along with successful performance up to 12 months.
- False-Positive Uptake on Radioiodine Whole-Body Scan Due to BronchiectasisPublication . Espírito Santo, R; Marques, P; Bugalho, MJ
- Formas Atípicas de Hipoacúsia em Doentes com o Diagnóstico de Neurinoma do AcústicoPublication . Sousa, H; Ferreira, R; Cardoso, I; Baptista, S; Ribeiro, C; Sousa, V; Marques, PA hipoacúsia neurosensorial unilateral e progressiva é uma das principais manisfestações audiológicas dos doentes com diagnóstico de neurinoma do acústico, estando no entanto descritas outras formas de apresentação. Dos 43 doentes com diagnóstico de neurinoma do acústico, tratados pela equipa de otoneurocirurgia entre 1997 e 2003, identificamos 88,5% com hipoacústica neurosensorial unilateral, 4,6% como hipoacústica neurosensorial súbita, 4,6% com audição simétrica e 2,3% com audição "normal". Estes dados revelam a existência de três formas incomuns de apresentação dos neurinomas, facto que deve levar os otorrinolaringologistas a manterem um elevado grau de alerta perante doentes com queixas que possam sugerir, de algum modo, a presença de neurinoma do acústico.
- Hipotiroidismo Associado a Anticorpos Anti-Receptor da Hormona TSH com Ação Bloqueadora Determinada In VitroPublication . Marques, P; Chikh, K; Charrié, A; Pina, R; Bugalho, MJ; Lopes, LThyroid-stimulating hormone-receptor autoantibodies normally causes hyperthyroidism. However, they might have blocking activity causing hypothyroidism. A 11-year-old girl followed due to type 1 diabetes mellitus, celiac disease and euthyroid lymphocytic thyroiditis at diagnosis. Two years after the initial evaluation, thyroid-stimulating hormone was suppressed with normal free T4; nine months later, a biochemical evolution to hypothyroidism with thyroid-stimulating hormone-receptor autoantibodies elevation was seen; the patient remained always asymptomatic. Chinese hamster ovary cells were transfected with the recombinant human thyroid-stimulating hormone -receptor, and then exposed to the patient's serum; it was estimated a 'moderate' blocking activity of these thyroid-stimulating hormone-receptor autoantibodies, and concomitantly excluded stimulating action. In this case, the acknowledgment of the blocking activity of the serum thyroid-stimulating hormone-receptor autoantibodies, supported the hypothesis of a multifactorial aetiology of the hypothyroidism, which in the absence of the in vitro tests, we would consider only as a consequence of the destructive process associated to lymphocytic thyroiditis.
- Severe Gastrointestinal Autonomic Dysfunction in a Diabetic BoyPublication . Marques, P; Varandas, L; Lopes, L
- Tiroidite Subaguda e Tuberculose: Associação ou Coincidência.Publication . Brandão, C; Marques, P; Limbert, C; Gouveia, C; Varandas, LA tiroidite é a patologia tiroideia mais comum em idade pediátrica, geralmente de etiologia auto-imune, sendo que a tiroidite subaguda é uma condição incomum nesta faixa etária. A tuberculose tiroideia é uma entidade rara, mesmo nos países onde a prevalência de tuberculose é elevada, como em Portugal. Estas patologias podem manifestar-se de forma variável, desde a presença de um nódulo isolado até quadros de tirotoxicose, o que dificulta o diagnóstico diferencial