Browsing by Author "Mateus Marques, R"
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- Esophageal Cancer: Results of the Trimodal Approach in a Medium-Volume Multidisciplinary UnitPublication . Carrola Gomes, D; Caldeira Fradique, A; Costa, L; Quaresma, L; Gualdino Silva, J; Vasconcelos, V; Sacadura, J; Oliveira, M; Esteves, J; Mateus Marques, R; Fernandez, G; Guedes da Silva
- Gastric MANECs: a Casuistic of a Portuguese CentrePublication . Aguiar, C; Caldeira Fradique, A; Quaresma, L; Matias, R; Gualdino Silva, J; Vasconcelos, V; Sacadura, J; Oliveira, M; Cabrita, F; Mateus Marques, R; Esteves, J; Costa, L; Fernandez, G; Guedes da Silva
- Índice Proliferativo Ki-67 no Cancro GástricoPublication . Nabais, C; Fradique, AC; Costa, L; Cabrita, F; Pupo, A; Quaresma, L; Silva, G; Mateus Marques, R; Esteves, J; Guedes da Silva, J; Oliveira, M; Pina, FIntrodução: O cancro gástrico representa ainda uma das principais causas de mortalidade por doença oncológica a nível mundial, apesar da evolução substancial no seu tratamento. Diversos marcadores biológicos têm sido introduzidos com intuito prognóstico da doença. A proteína Ki-67 através de técnicas imunocitoquímicas tem sido utilizada como um indicador da actividade proliferativa tumoral. No cancro gástrico o seu valor prognóstico ainda não foi estabelecido, sendo os resultados na literatura controversos. Este estudo pretende avaliar o significado biológico do índice proliferativo Ki-67 no cancro gástrico. Métodos: Foram estudados 50 doentes com cancro gástrico submetidos a cirurgia ressectiva. A proteína Ki-67 foi analisada por imunocitoquímica nas peças operatórias. O índice proliferativo Ki-67 foi definido como a percentagem de células tumorais positivas para a proteína. Resultados: Dos 50 casos estudados foi obtido um índice proliferativo Ki-67 de 68.9 ± 24.1%. Foram correlacionadas as variáveis sexo, idade, localização e dimensão tumoral, classificação TNM, estadio e tipo histológico de Lauren. Apenas esta última revelou diferenças estatisticamente significativas entre os respectivos tipos (P = 0.004). Conclusão: Os achados encontrados não permitem definir inequivocamente o valor prognóstico do índice proliferativo Ki-67. Será importante prosseguir o estudo com uma amostra populacional superior, para que conclusões estatisticamente significativas possam ser elaboradas.
- Ki-67 Proliferation Index in Gastric Cancer - Biologic SignificancePublication . Nabais, C; Caldeira Fradique, A; Oliveira, M; Quaresma, L; Gualdino Silva, J; Vasconcelos, V; Sacadura, J; Costa, L; Cabrita, F; Mateus Marques, R; Esteves, J; Fernandez, G; Guedes da SilvaObjectives/Introdution: Ki-67 protein has been used as an indicator of proliferation activity in tumor cells. In gastric cancer the prognostic value has not been fully understood. This study was designed to assess the biologic significance of Ki-67 proliferation index (PI) in gastric cancer. Material/Methods: Seventy-two patients with gastric cancer were evaluated. These patients underwent gastric resection, and the tumor tissue was stained immunohistochemically. Ki-67 PI was defined as the percentage of tumor cells positive for Ki-67. Ki-67 PI was correlated with clinicopathological characteristics and patient survival. Results: A low Ki-67 PI (less than or equal to 50%) was associated with poorly differentiated histology - diffuse type (p=0.009) and signet ring cells (p=0.004) - and younger age (p=0.022). A worse prognosis in patients with low Ki-67 PI was also found (a mean survival of 41.8 vs 63 months for high Ki-67 PI group), but not statistically significant (p=0.623, log rank test). Discussion/Conclusion: We found an inversely correlation between Ki-67 PI and histological differentiation grade. Patients in group with low Ki-67 PI are younger, with poorly differentiated histology and have a lower mean survival. Like other studies already suggested, we may have two different tumors phenotypes - highly invasive with low proliferative capability, and less invasive potential with higher proliferative ability. However, in this sample, no significant prognostic value was achieved between both.
- Neuroendocrine Carcinoma of the Esophagus: Single-Center Experience of 5 CasesPublication . Corado, S; Caldeira Fradique, A; Figueiredo, J; Quaresma, L; Pupo, A; Sacadura, J; Vasconcelos, V; Gualdino Silva, J; Fernandez, G; Costa, L; Mateus Marques, R; Oliveira, M; Esteves, J; Guedes da Silva; Barroso, E
- Perforated Meckel's Diverticulum in an AdultPublication . Camelo, R; Santos, P; Mateus Marques, RMeckel's diverticulum is the commonest congenital anomaly of the gastrointestinal tract. Its complications have an extensive variety of clinical and imaging manifestations, extending from benign and indolent findings to acute life-threatening conditions. Complicated Meckel's diverticulum often constitutes a challenging diagnosis for both the clinician and the radiologist. Therefore, imaging techniques play an important role in this condition in evaluating its complications, determining decision making. We describe a case of a 49-year-old man suffering from right abdominal pain with fever and constipation, during the past 5 days. Laboratory data revealed C-reactive protein of 306 mg/L and leukocytosis. Contrast-enhanced CT features were highly suggestive of perforated Meckel's diverticulum. The purpose of this article is to emphasize that besides its rarity, Meckel's diverticulum complications can occur in adult patients.
- Post-Treated Prostate Cancer: Normal Findings and Signs of Local Relapse on Multiparametric Magnetic Resonance ImagingPublication . Lopes Dias, J; Lucas, R; Pina, J; João, R; Costa, N; Leal, C; Bilhim, T; Campos Pinheiro, L; Mateus Marques, RThe use of multiparametric magnetic resonance imaging (mp-MRI) for prostate cancer has increased over recent years, mainly for detection, staging, and active surveillance. However, suspicion of recurrence in the set of biochemical failure is becoming a significant reason for clinicians to request mp-MRI. Radiologists should be able to recognize the normal post-treatment MRI findings. Fibrosis and atrophic remnant seminal vesicles after prostatectomy are often found and must be differentiated from local relapse. Moreover, brachytherapy, external beam radiotherapy, cryosurgery, and hormonal therapy tend to diffusely decrease the signal intensity of the peripheral zone on T2-weighted images (T2WI) due to the loss of water content, consequently mimicking tumor and hemorrhage. The combination of T2WI and functional studies like diffusion-weighted imaging and dynamic contrast-enhanced improves the identification of local relapse. Tumor recurrence tends to restrict on diffusion images and avidly enhances after contrast administration either within or outside the gland. The authors provide a pictorial review of the normal findings and the signs of local tumor relapse after radical prostatectomy, external beam radiotherapy, brachytherapy, cryosurgery, and hormonal therapy.
- Prostate Cancer: Dynamic Contrast-Enhanced MR ImagingPublication . Lopes Dias, J; Fialho, J; Alves, P; Almeida, C; Cordeiro, AR; Mateus Marques, R
- Prostate Cancer: The Role of Multiparametric Magnetic Resonance ImagingPublication . Lopes Dias, J; Pina, J; João, R; Fialho, J; Carmo, S; Leal, C; Bilhim, T; Mateus Marques, R; Campos Pinheiro, LMultiparametric Magnetic Resonance Imaging has been increasingly used for detection, localization and staging of prostate cancer over the last years. It combines high-resolution T2 Weighted-Imaging and at least two functional techniques, which include Dynamic Contrast–Enhanced Magnetic Resonance Imaging, Diffusion-Weighted Imaging, and Magnetic Resonance Imaging Spectroscopy. Although the combined use of a pelvic phased-array and an Endorectal Coil is considered the state-of-the-art for Magnetic Resonance Imaging evaluation of prostate cancer, Endorectal Coil is only absolute mandatory for Magnetic Resonance Imaging Spectroscopy at 1.5 T. Sensitivity and specificity levels in cancer detection and localization have been improving with functional technique implementation, compared to T2 Weighted-Imaging alone. It has been particularly useful to evaluate patients with abnormal PSA and negative biopsy. Moreover, the information added by the functional techniques may correlate to cancer aggressiveness and therefore be useful to select patients for focal radiotherapy, prostate sparing surgery, focal ablative therapy and active surveillance. However, more studies are needed to compare the functional techniques and understand the advantages and disadvantages of each one. This article reviews the basic principles of prostatic mp-Magnetic Resonance Imaging, emphasizing its role on detection, staging and active surveillance of prostate cancer.
- Sentinel Lymph Node in Gastric CancerPublication . Quaresma, L; Caldeira Fradique, A; Oliveira, M; Gualdino Silva, J; Vasconcelos, V; Sacadura, J; Mateus Marques, R; Esteves, J; Costa, L; Fernandez, G; Guedes da Silva