Browsing by Author "Mesquita, I"
Now showing 1 - 10 of 11
Results Per Page
Sort Options
- Acute Allograft Kidney Dysfunction 18 Years After TransplantationPublication . Viana, H; Mesquita, I; Aires, I; Carvalho, F; Nolasco, F
- Acute Kidney Injury in an HIV and HCV PatientPublication . Viana, H; Mesquita, I; Calado, J; Nolasco, F; Carvalho, F
- An Unexpected Cause of Chronic Renal Dysfunction and Haemato-ProteinuriaPublication . Sousa Viana, H; Mesquita, I; Pataca, I; Carvalho, F; Nolasco, F
- Idiopathic Hypocomplementaemic Tubulointerstitial NephritisPublication . Azevedo, A; Mesquita, I; Viana, H; Rocha, G; Ferreira, C; Fernandes, V; Murinello, A; Carvalho, F; Nolasco, FBackground: Tubulointerstitial nephritis (TIN) is a common cause of kidney injury typically seen in association with drug exposure, infection or autoimmune diseases. However, TIN with interstitial immune complex deposition, without glomerular injury, is rarely observed. Case: We report a case of a 64-yearold Indian woman admitted for dialysis-requiring renal failure, without involvement of other organs. Urinalysis showed blood 3+ and 24h proteinuria of 1.5 g. Renal ultrasound revealed normal sized kidneys with loss of parenchymal-sinus differentiation. Laboratory tests disclosed low C3, positive ANA but negative anti-dsDNA, SSA and SSB. Serum protein electrophoresis was normal. The renal biopsy showed tubulointerstitial nephritis with positive immunoglobulin staining involving the interstitium and tubular basement membrane with glomerular sparing. The patient started prednisolone (1mg/kg/day) without recovery of the renal function. Conclusion: Idiopathic hypocomplementaemic tubulointerstitial nephritis is a rare disease with few cases described in the literature. To our knowledge this is the first case reported in Portugal.
- Kidney Biopsy in Monoclonal GammopathiesPublication . Mesquita, I; Góis, M
- Morphologic Patterns and Treatment of Transplant Glomerulopathy: a Retrospective AnalysisPublication . Abreu, R; Carvalho, F; Viana, H; Mesquita, I; Possante, M; Aires, I; Caeiro, F; Silva, C; Cotovio, P; Ferreira, A; Remédio, F; Nolasco, FTransplant glomerulopathy is mainly due to chronic antibody-mediated rejection and actually represents a major cause of long-term allograft failure. The lack of effective treatment remains a serious problem in transplantation. A retrospective and uni-center study was performed in 48 kidney allograft recipients with transplant glomerulopathy between January 2010 and December 2015. Median time for diagnosis was 7.1 (3.6-11.8) years post-transplant. Light microscopy showed severity of transplant glomerulopathy in the majority of patients (cg1=10.4%; cg2=20.8%; cg3=68.8%). Moderate microvascular inflammation was present in 56.3% (g+ptc≥2), and almost half of recipients (51.1%) were C4d positive in immunofluorescence. Female gender (P=.001), age (P=.043), renal dysfunction (P=.002), acute rejection episodes (P=.026), and anti-HLA class II antibodies (P=.004) were associated with kidney allograft failure. Treatment of transplant glomerulopathy was performed in 67.6% of patients. The histologic and laboratory features that led to a therapeutic intervention were score ptc (P=.021), C4d (P=.03), and the presence of anti-HLA antibodies (P=.029), whereas score ah (P=.005) was associated with conservative measure. The overall cumulative kidney allograft survival at 10 years was 75%. Treatment of transplant glomerulopathy was ineffective to improve long-term kidney allograft survival.
- Nephrotic Syndrome in HIV/HCV Co-Infected PatientPublication . Viana, H; Mesquita, I; Azevedo, A; Ribeiro, F; Carvalho, F; Nolasco, F
- A New Anatomo-Clinical Approach to an Old DiseasePublication . Sousa Viana, H; Góis, M; Mesquita, I; Santos, AR; Santos, MC; Carvalho, F; Nolasco, F
- A Rare Malignancy in the Post -Transplant Period: Myeloma Cast NephropathyPublication . Mesquita, I; Viana, H; Possante, M; João, C; Carvalho, S; Silva, C; Aires, I; Ferreira, A; Remédio, F; Carvalho, F; Nolasco, FMyeloma-associated renal disorders are rare events among renal transplants and can occur as recurrent or de novo disease. We describe an unusual case of renal allograft dysfunction due to myeloma cast nephropathy occurring 19 years after having received a renal transplant in a patient with no prior history of multiple myeloma or monoclonal gammopathy preceding transplantation. Our patient was treated with five cycles of chemotheraphy(bortezomib, melphalan and steroids), which resulted in short-term improvement in allograft dysfunction and complete haematological remission. The longer patient and graft survival after renal transplantation make post-transplant lymphoproliferative disease more frequent. Multiple myeloma after kidney transplant is rare and an elevated index of suspicion is necessary to make a timely diagnosis of this serious disease. Further work is needed to identify the best treatment options for these patients.
- A Rare Morphologic Pattern in a Common Disease, or Two Diseases?Publication . Góis, M; Valada Marques, A; Mesquita, I; Sousa, H; Carvalho, F; Nolasco, F