Browsing by Author "Oliveira, C"
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- Effects of Sevelamer Hydrochloride and Calcium Carbonate on Renal Osteodystrophy in Hemodialysis PatientsPublication . Ferreira, A; Frazão, JM; Monier-Faugere, MC; Gil, C; Galvão, J; Oliveira, C; Baldaia, J; Rodrigues, I; Santos, C; Ribeiro, S; Hoenger, R; Duggal, A; Malluche, HHDisturbances in mineral metabolism play a central role in the development of renal bone disease. In a 54-wk, randomized, open-label study, 119 hemodialysis patients were enrolled to compare the effects of sevelamer hydrochloride and calcium carbonate on bone. Biopsy-proven adynamic bone disease was the most frequent bone abnormality at baseline (59%). Serum phosphorus, calcium, and intact parathyroid hormone were well controlled in both groups, although calcium was consistently lower and intact parathyroid hormone higher among patients who were randomly assigned to sevelamer. Compared with baseline values, there were no changes in mineralization lag time or measures of bone turnover (e.g., activation frequency) after 1 yr in either group. Osteoid thickness significantly increased in both groups, but there was no significant difference between them. Bone formation rate per bone surface, however, significantly increased from baseline only in the sevelamer group (P = 0.019). In addition, of those with abnormal microarchitecture at baseline (i.e., trabecular separation), seven of 10 in the sevelamer group normalized after 1 yr compared with zero of three in the calcium group. In summary, sevelamer resulted in no statistically significant changes in bone turnover or mineralization compared with calcium carbonate, but bone formation increased and trabecular architecture improved with sevelamer. Further studies are required to assess whether these changes affect clinical outcomes, such as rates of fracture.
- Haemophilia A: Health and Economic Burden of a Rare Disease in PortugalPublication . Café, A; Carvalho, M; Crato, M; Faria, M; Kjollerstrom, P; Oliveira, C; Pinto, PR; Salvado, R; Dos Santos, AA; Silva, CHaemophilia A is a hereditary bleeding disorder, which has been considered rare and chronic. The burden of this disease in Portugal remains unknown. The aim of this study was to estimate the annualized cost and health burden of haemophilia A in Portugal.
- Maus Tratos na Primeira Infância – A Experiência de Um Hospital TerciárioPublication . Stilwell, MR; Oliveira, C; Silva, P; Sousa, S; Ismail, D; Sassetti, LIntrodução: Os maus tratos (MT) na infância, têm repercussões na vida da criança e das comunidades. A identificação, particularmente difícil em estádios precoces do desenvolvimento, é essencial para a interrupção precoce dos MT. Objectivo: Caracterizar os casos sinalizados como MT até aos 3 anos de idade, num hospital terciário. Material e métodos: Estudo retrospectivo descritivo das sinalizações de crianças dos 0 aos 2 anos, no período de 2015 a 2017, atendendo ao sexo, família, forma de MT, origem da sinalização, agressor e se este coabitava com a criança. Resultados: Dos 460 casos reportados como MT, 72 (16%) pertenciam à faixa etária avaliada. A distribuição foi semelhante entre os sexos (33M-39F). Na maioria, vinham de famílias nucleares (31) ou monoparentais (22); foram sinalizadas pela Urgência (58-80%); a principal forma de MT foi a negligência (43- 60%) – estas crianças residiam maioritariamente com os pais. As sinalizações associadas a violência (19 por agressão física, 8 de abuso sexual (AS) e 2 exposição a violência doméstica) distribuíram-se por famílias monoparentais (11) seguida das nucleares (10), reconstruídas (5) e alargadas (3). Em 21 casos o agressor pertencia à família, em 13 era coabitante. Das 8 notificação por AS, em 5 a família era monoparental, o agressor era familiar em 6, só em 2 eram coabitantes. Conclusões: A identificação e prevenção de MT neste grupo etário é delicada, pois os agressores tendem a ser próximos da criança, e são até, muitas vezes, quem a traz ao SU. Nos últimos anos, tem-se verificado um aumento das situações suspeitas de abuso sexual, algumas configurando casos de alienação parental. Todos estes aspectos exigem particular atenção dos profissionais de saúde, particularmente no SU, habitual porta de entrada destas situações.
- Renal Transplantation in HIV-Infected Patients: The First Portuguese ReviewPublication . Querido, S; Machado, D; Silva, C; Nolasco, F; Nunes, A; Sampaio, S; Cruz, P; Oliveira, C; Weigert, AINTRODUCTION: With the introduction of combination antiretroviral therapy (cART), prognosis of human immunodeficiency virus (HIV) infection has been improved and kidney transplantation (KT) in HIV-positive patients became possible. METHODS: We reviewed the demographic, clinical, laboratory, and therapeutic data of all the HIV-infected patients who underwent KT between 2009 (first KT in Portugal in a HIV-infected patient) and May 2014. Case accrual was through all Portuguese KT centers where a KT in an HIV-infected patient was performed. Patients were transplanted following the American and Spanish guideline recommendations that included maintenance on cART, undetectable plasma HIV RNA copies, and absolute CD4 counts of ≥ 200 cells/μL in the last 6 months. RESULTS: Fourteen KT were performed on men and 3 on women. The mean age of patients at the time of transplantation was 49.9 ± 11.7 years. HIV status was known for 12 ± 5 years. Eight patients had AIDS in the past and all patients received grafts from deceased donors. Twelve patients (64.7%) underwent induction therapy with basiliximab and 2 patients experienced early graft loss. In 2 patients, humoral rejection was diagnosed and in 3 patients, cellular rejection. Two patients died and an additional patient had early graft loss. CONCLUSION: KT is a possible, but challenging, renal replacement therapy in selected HIV-positive patients. Even in those with AIDS criteria in the past, when the disease is controlled, and after the reconstitution of the immune system with cART, KT can be performed. Nevertheless, the risk-benefit ratio for each patient needs to be taken in consideration.
- Women's Attachment as a Predictor of Pain During Labour and Post-Delivery: a Prospective Observational StudyPublication . Costa Martins, JM; Fernandes da Silva, C; Pereira, M; Martins, H; Oliveira, C; Puga, A; Coelho, R; Tavares, JINTRODUCTION: Labour is considered to be one of the most painful and significant experiences in a woman's life. The aim of this study was to examine whether women's attachment style is a predictor of the pain experienced throughout labour and post-delivery. MATERIAL AND METHODS:Thirty-two pregnant women were assessed during the third trimester of pregnancy and during labour. Adult attachment was assessed with the Adult Attachment Scale ' Revised. The perceived intensity of labour pain was measured using a visual analogue scale for pain in the early stage of labour, throughout labour and post-delivery. RESULTS:Women with an insecure attachment style reported more pain at 3 cm of cervical dilatation (p < 0.05), before the administration of analgesia (p < 0.01) and post-delivery (p < 0.05) than those securely attached. In multivariate models, attachment style was a significant predictor of labour pain at 3 cm of cervical dilatation and before the first administration of analgesia but not of the perceived pain post-delivery. DISCUSSION: These findings confirm that labour pain is influenced by relevant psychological factors and suggest that a woman's attachment style may be a risk factor for greater pain during labour. CONCLUSION:Future studies in the context of obstetric pain may consider the attachment style as an indicator of individual differences in the pain response during labour. This may have important implications in anaesthesiology and to promote a relevant shift in institutional practices and therapeutic procedures.