Browsing by Author "Varandas, L"
Now showing 1 - 10 of 37
Results Per Page
Sort Options
- Actinomycetoma by Cellulosimicrobium Cellulans in a Young Man from Guinea-Bissau: Short Literature Review Regarding a Case ReportPublication . Trindade Torres, M; Sousa Nunes, B; Varandas, L; Maltez, FMycetoma is caused by the subcutaneous inoculation of filamentous fungi or aerobic filamentous bacteria. Cellulosimicrobium cellulans is a gram-positive bacterium from the order Actinomycetales that rarely causes human disease. The diagnosis is based on the clinical presentation and identification of the causative microorganism. We present a short literature review regarding the case report of a young man diagnosed with actinomycetoma due to Cellulosimicrobium cellulans and who received treatment with an association of amikacin and sulfamethoxazole/ trimethoprim (Welsh regimen).
- A Case of Complicated Ascaris InfectionPublication . Moreira, T; Bota, S; Carvalho, MR; Cordeiro, AI; Gouveia, C; Varandas, L
- CAT-SCRATCH Disease: Still a ChallengePublication . Bota, S; Jacinto, S; Ferreira, C; Santos, AS; Varandas, L; Gouveia, C
- Clinical, Laboratorial and Immunological Aspects of Severe Malaria in Children from Guinea-BissauPublication . Domingos, J; Casimiro, A; Portugal-Calisto, D; Varandas, L; Nogueira, F; Silva, M SMalaria is a parasitic disease of which Plasmodium falciparum causes the most severe form of the disease. The immune response against Plasmodium spp. is complex and remains unclear. The present report aimed to better understand the humoral immune response in severe malaria and analyse new immunodominant antigen candidates as possible serological marker in severe malaria in children. This study included children aged 0-16 years from Guinea-Bissau with clinical signs of severe malaria. Serological and immunochemical characterisation of different anti-P. falciparum antibodies were made by ELISA and immunoblotting using a crude protein extract of P. falciparum. Sera from 12 children with severe malaria were analysed. Nine samples were positive for total anti-P. falciparum antibodies, seven for IgM and eight for total IgG anti-P. falciparum. There was a predominance of IgG1 response, suggesting a cytophilic action in severe malaria and a major role of IgG1 over other immunoglobulins. The antigenic profile of P. falciparum showed a consistent immunoblotting pattern of approximately 180 kDa, 100 kDa and around 50-40 kDa. The serological reactivity found in protein bands makes them as immunodominant antigens and promising candidates for serological markers in the context of severe malaria.
- Clostridium Difficile in a Tertiary Pediatric HospitalPublication . Bota, S; Varandas, L; Cordeiro-Ferreira, G; Gouveia, C
- Clostridium Difficile: Quando Valorizar?Publication . Bota, S; Varandas, L; Brito, MJ; Gouveia, C
- Colecistite Aguda Alitiásica - Uma Forma Rara de Hepatite APublication . Madeira Gomes, S; Campos, A; Nóbrega, S; Varandas, L; Gouveia, C
- Community-Associated Methicillin-Resistant Staphylococcus Aureus Lacking PVL, as a Cause of Severe Invasive Infection Treated with LinezolidPublication . Gouveia, C; Gavino, A; Bouchami, O; Miragaia, M; Varandas, L; Lencastre, H; Brito, MJCommunity-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) is an emerging public health problem worldwide. Severe invasive infections have been described, mostly associated with the presence of Panton-Valentine leukocidin (PVL). In Portugal limited information exists regarding CA-MRSA infections. In this study we describe the case of a previously healthy 12-year-old female, sport athlete, who presented to the hospital with acetabulofemoral septic arthritis, myositis, fasciitis, acetabulum osteomyelitis, and pneumonia.The MRSA isolated from blood and synovial fluid was PVL negative and staphylococcal enterotoxin type P (SEP) and type L (SEL) positive, with a vancomycin MIC of 1.0mg/L and resistant to clindamycin and ciprofloxacin. The patient was submitted to multiple surgical drainages and started on vancomycin, rifampicin, and gentamycin. Due to persistence of fever and no microbiological clearance, linezolid was started with improvement. This is one of the few reported cases of severe invasive infection caused by CA-MRSA in Portugal,which was successfully treated with linezolid. In spite of the severity of infection, the MRSA isolate did not produce PVL.
- Complicações Intracranianas na Mastoidite: É Possível Melhorar o PrognósticoPublication . Garcia, AM; Gouveia, C; Vieira, JP; Soares Cunha, I; Varandas, L; Brito, MJA otomastoidite é a complicação supurativa mais comum da otite média aguda. Pode cursar com complicações intracranianas em 17% dos casos, como a meningite ou trombose venosa do seio lateral (TVSL). A abordagem nem sempre é consensual e a hipertensão craniana secundária pode ser uma complicação
- Doença de Kawasaki e Fleimão Retrofararíngeo: Uma Doença?Publication . Garcia, AM; Laranjo, S; Pinto, F; Gouveia, C; Varandas, L