Publication
High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS)
| dc.contributor.author | Carvalho, D | |
| dc.contributor.author | Mendonça, C | |
| dc.contributor.author | Carvalho, J | |
| dc.contributor.author | Martins, A | |
| dc.contributor.author | Leal, A | |
| dc.date.accessioned | 2023-01-11T15:33:56Z | |
| dc.date.available | 2023-01-11T15:33:56Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Objective: Continuous Spike-Wave during slow Sleep (CSWS) syndrome associates a clinically important neurocognitive regression with strong activation of non-REM sleep spikes. Its mechanisms remain unknown, but a contribution of rare perinatal thalamic injuries has been highlighted. We determine the incidence of such lesions in a cohort of CSWS patients. Methods: N = 65 patients with CSWS and a control group (N = 51) were studied. Spikes were quantified in long-term ambulatory EEGs, brain Magnetic Ressonance Imaging (MRI) structural lesions were assessed and thalamic volumetry was performed. A neurocognitive scale was used to assess dysfunction. Results: The most common etiologies in the control patients were not represented in the CSWS group. Structural lesions were detected in a minority of CSWS patients (25/53) but included a thalamic injury in the large majority (24/25). This ratio was 4/40 in controls. Lesions belonged to one of five types: 1. Circumscribed to the thalamus (N = 11); 2. Extending beyond the thalamus (N = 3); 3. Hypothalamic-Hamartomas (N = 4); 4. Periventricular-Leukomalacia (N = 4); 5. Hypoplasia-Polymicrogyria (N = 1). Most lesions were lateralized to one hemisphere, which in all cases corresponded to the lateralization of the CSWS. Significance: Thalamic lesions are present in most CSWS patients with abnormal MRIs, supporting an important role in its genesis. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Epilepsy Behav . 2023 Jan;138:109031 | pt_PT |
| dc.identifier.doi | 10.1016/j.yebeh.2022.109031 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/4353 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.subject | CSWS | pt_PT |
| dc.subject | CSWS | pt_PT |
| dc.subject | Epileptic Encephalopathy | pt_PT |
| dc.subject | Pediatric Epilepsy | pt_PT |
| dc.subject | Thalamus | pt_PT |
| dc.subject | HDE NEU PED | pt_PT |
| dc.title | High Incidence of Early Thalamic Lesions in the Continuous Spike-Wave Related with Slow Sleep (CSWS) | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.startPage | 109031 | pt_PT |
| oaire.citation.title | Epilepsy & Behavior | pt_PT |
| oaire.citation.volume | 138 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |