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Publication
The Utility of Apparent Diffusion Coefficient Values in the Risk Stratification of Prostate Cancer Using a 1.5 T Magnetic Resonance Imaging Without Endorectal Coil
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Advisor(s)
Abstract(s)
Purpose: To evaluate the relationship between mean apparent diffusion coefficient (ADC) and
post-surgical Gleason scores. To determine the diagnostic accuracy of multiparametric magnetic
resonance imaging (mp-MRI) on a 1.5 T magnet in distinguishing low, intermediate and highgrade
prostate tumors.
Material and methods: This is a retrospective institutional-review-board-approved, singlecenter
study including 30 patients (median age, 60 years) who underwent mp-MRI before
prostatectomy for prostate cancer. Using histological reports for guidance, the tumors were
localized in ADC maps, and mean ADCs were measured and examined for correlation with
Gleason scores. 2 patients had 2 measurable foci, so a total of 32 tumors were studied. The diagnostic
accuracy of the mean ADC was assessed by using the area under the receiver operating
characteristic curve (ROC).
Results: In the differentiation of tumors with a Gleason score of 6 from those with a Gleason
score of at least 7, mean ADC yielded an AUC of 0.76 (95% confidence interval: 0.59, 0.93). In
the differentiation of tumors with Gleason scores of 6 or 7 from those with a Gleason score of
at least 8, mean ADC yielded an AUC of 0.94 (95% confidence interval: 0.86, 1.00).
Conclusion: Mean ADC values may allow a correct assessment of the patient risk using a 1.5 T
magnet without ERC.
Description
Keywords
Multiparametric Magnetic Resonance Imaging Prostate Cancer Apparent Diffusion Coefficient Gleason Score Risk Stratification HSJ IMA HSJ URO
Citation
Acta Urol Port. 2016;33(3):81-86
Publisher
Associação Portuguesa de Urologia