Publication
Sepsis Mortality Prediction Based on Predisposition, Infection and Response
| dc.contributor.author | Moreno, R | |
| dc.contributor.author | Metnitz, B | |
| dc.contributor.author | Adler, L | |
| dc.contributor.author | Hoechtl, A | |
| dc.contributor.author | Bauer, P | |
| dc.contributor.author | Metnitz, P | |
| dc.contributor.author | SAPS 3 Investigators | |
| dc.date.accessioned | 2013-08-06T16:31:16Z | |
| dc.date.available | 2013-08-06T16:31:16Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | OBJECTIVE: To empirically test, based on a large multicenter, multinational database, whether a modified PIRO (predisposition, insult, response, and organ dysfunction) concept could be applied to predict mortality in patients with infection and sepsis. DESIGN: Substudy of a multicenter multinational cohort study (SAPS 3). PATIENTS: A total of 2,628 patients with signs of infection or sepsis who stayed in the ICU for >48 h. Three boxes of variables were defined, according to the PIRO concept. Box 1 (Predisposition) contained information about the patient's condition before ICU admission. Box 2 (Injury) contained information about the infection at ICU admission. Box 3 (Response) was defined as the response to the infection, expressed as a Sequential Organ Failure Assessment score after 48 h. INTERVENTIONS: None. MAIN MEASUREMENTS AND RESULTS: Most of the infections were community acquired (59.6%); 32.5% were hospital acquired. The median age of the patients was 65 (50-75) years, and 41.1% were female. About 22% (n=576) of the patients presented with infection only, 36.3% (n=953) with signs of sepsis, 23.6% (n=619) with severe sepsis, and 18.3% (n=480) with septic shock. Hospital mortality was 40.6% overall, greater in those with septic shock (52.5%) than in those with infection (34.7%). Several factors related to predisposition, infection and response were associated with hospital mortality. CONCLUSION: The proposed three-level system, by using objectively defined criteria for risk of mortality in sepsis, could be used by physicians to stratify patients at ICU admission or shortly thereafter, contributing to a better selection of management according to the risk of death. | por |
| dc.identifier.citation | Intensive Care Med. 2008 Mar;34(3):496-504 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/1428 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Springer | por |
| dc.subject | Doença Crónica | por |
| dc.subject | Infecções Comunitárias Adquiridas | por |
| dc.subject | Infecção Hospitalar | por |
| dc.subject | Mortalidade | por |
| dc.subject | Bases de Dados Factuais | por |
| dc.subject | Susceptibilidade a Doença | por |
| dc.subject | Infecções por Bactérias Gram-Positivas | por |
| dc.subject | Mortalidade Hospitalar | por |
| dc.subject | Unidades de Cuidados Intensivos | por |
| dc.subject | Sépsis | por |
| dc.subject | Índice de Gravidade da Doença | por |
| dc.subject | Insuficiência de Múltiplos Órgãos | por |
| dc.subject | Choque Séptico | por |
| dc.subject | Microbiologia | por |
| dc.subject | Síndrome de Resposta Inflamatória Sistémica | por |
| dc.title | Sepsis Mortality Prediction Based on Predisposition, Infection and Response | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 504 | por |
| oaire.citation.startPage | 496 | por |
| oaire.citation.title | Intensive Care Medicine | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |