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Clinical Outcomes and Genetic Expression Profile in Human Liver Graft Dysfunction During Ischemia/Reperfusion Injury

2015Journal article Open access
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dc.contributor.authorPaulino, J
dc.contributor.authorVigia, E
dc.contributor.authorMarcelino, P
dc.contributor.authorAbade, O
dc.contributor.authorSobral, J
dc.contributor.authorLigeiro, D
dc.contributor.authorCarvalho, A
dc.contributor.authorAlves, M
dc.contributor.authorPapoila, AL
dc.contributor.authorTrindade, H
dc.contributor.authorBarroso, E
dc.date.accessioned2015-08-25T11:41:08Z
dc.date.available2015-08-25T11:41:08Z
dc.date.issued2015
dc.description.abstractIntroduction. This study aims to compare the molecular gene expression during ischemia reperfusion injury. Several surgical times were considered: in the beginning of the harvesting (T0), at the end of the cold ischemia period (T1), and after reperfusion (T2) and compared with graft dysfunction after liver transplant (OLT). Methods. We studied 54 patients undergoing OLT. Clinical, laboratory data, and histologic data (Suzuki classification) as well as the Survival Outcomes Following Liver Transplantation (SOFT) score were used and compared with the molecular gene expression of the following genes: Interleukin (IL)-1b, IL-6, tumor necrosis factor-a, perforin, E-selectin (SELE), Fas-ligand, granzyme B, heme oxygenase-1, and nitric oxide synthetase. Results. Fifteen patients presented with graft dysfunction according to SOFT criteria. No relevant data were obtained by comparing the variables graft dysfunction and histologic variables. We observed a statistically significant relation between SELE at T0 (P ¼ .013) and IL-1b at T0 (P ¼ .028) and early graft dysfunction. Conclusions. We conclude that several genetically determined proinflammatory expressions may play a critical role in the development of graft dysfunction after OLT.por
dc.identifier.citationTransplant Proc. 2015 May;47(4):882-7por
dc.identifier.urihttp://hdl.handle.net/10400.17/2292
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectCold Ischemia/methodspor
dc.subjectHCC ANPATpor
dc.subjectHCC CHBPTpor
dc.subjectGene Expression Profiling/methods
dc.subjectGene Expression Regulation
dc.subjectGenetic Markers/genetics
dc.subjectLiver Diseases/genetics
dc.subjectLiver Diseases/metabolism
dc.subjectLiver Diseases/surgery
dc.subjectLiver Transplantation
dc.subjectMicroarray Analysis
dc.subjectRNA/genetics
dc.subjectReperfusion Injury/genetics
dc.subjectReperfusion Injury/metabolism
dc.subjectRetrospective Studies
dc.subjectTransplants/metabolism
dc.subjectTransplants/pathology
dc.titleClinical Outcomes and Genetic Expression Profile in Human Liver Graft Dysfunction During Ischemia/Reperfusion Injurypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage887por
oaire.citation.startPage882por
oaire.citation.volume47por
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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