Sustained Increase of Paediatric Invasive Streptococcus Pyogenes Infections Dominated by M1UK and Diverse Emm12 isolates, Portugal, September 2022 to May 2023

Gouveia, C; Bajanca-Lavado, MP; Mamede, R; Araújo Carvalho, A; Rodrigues, F; Melo-Cristino, J; Ramirez, M; Friães, A

http://hdl.handle.net/10400.17/4780

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Abstract(s)

ince autumn 2022, observed numbers of paediatric invasive group A Streptococcus infections in Portugal (n = 89) were higher than in pre-COVID-19 seasons. Between September 2022 and May 2023, the dominant diagnoses were pneumonia (25/79), mostly with empyema (20/25), and sepsis (22/79). A number of cases required admission to intensive care (27/79) and surgery (35/79), and the case fatality rate was 5.1% (4/79). Genomic sequencing (n = 55) revealed multiple genetic lineages, dominated by the M1UK sublineage (26/55) and more diverse emm12 isolates (12/55).

Keywords

COVID-19* Child Chromosome Mapping Portugal / epidemiology Streptococcal Infections* / diagnosis Streptococcal Infections* / epidemiology Streptococcus pyogenes / genetics United Kingdom HDE INF PED