Multidrug-Resistant Bacteria in Diabetic Foot Infections: Experience from a Portuguese Tertiary Centre

Pessoa E Costa, T; Duarte, B; João, AL; Coelho, M; Formiga, A; Pinto, M; Neves, J

http://hdl.handle.net/10400.17/3782

Use this identifier to reference this record.

Name:	Description:	Size:	Format:
Int Wound J 2020 2.pdf		662.96 KB	Adobe PDF	Download

Send Feedback

Authors

Abstract(s)

In recent years, the emergence of antibiotic resistant pathogens made increasingly difficult to establish appropriate empiric antimicrobial therapy protocols for acute diabetic foot infection (DFI) treatment. Early recognition of the population at-risk for multidrug-resistant (MDR) bacterial infection is of paramount importance in order to decrease large-spectrum antibiotic overuse. This study used retrospective cohort study in a multidisciplinary tertiary diabetic foot unit. Patients with severe DFI were included and divided according to their infection resistance profile (susceptible vs MDR bacteria). Data regarding their comorbidities and length of hospital stay were collected. The primary endpoint was to determine the risk factors for MDR infections and to evaluate if these were associated with an increased length of stay (LOS). A total of 112 microbial isolates were included. Predominance of Gram-positive bacteria was observed and 22.3% of isolated bacteria were MDR. Previous hospitalisation was associated with a higher likelihood of MDR infection. MDR bacterial infection was also associated with an increased LOS (P = .0296). Our study showed a high incidence of MDR bacteria in patients with a DFI, especially in those who had a recent hospitalisation. MDR infections were associated with a prolonged LOS and represent a global public health issue for which emergent measures are needed.

Keywords

HSAC DER CHLC CIR CHLC PAT CLIN Humans Bacteria Anti-Bacterial Agents / pharmacology Anti-Bacterial Agents / therapeutic use Diabetes Mellitus* / drug therapy Diabetic Foot* / drug therapy Diabetic Foot* / epidemiology Drug Resistance, Multiple, Bacterial Gram-Negative Bacteria Microbial Sensitivity Tests Portugal / epidemiology Retrospective Studies