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Multidrug-Resistant Bacteria in Diabetic Foot Infections: Experience from a Portuguese Tertiary Centre

2020-12Journal article Open access
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dc.contributor.authorPessoa E Costa, T
dc.contributor.authorDuarte, B
dc.contributor.authorJoão, AL
dc.contributor.authorCoelho, M
dc.contributor.authorFormiga, A
dc.contributor.authorPinto, M
dc.contributor.authorNeves, J
dc.date.accessioned2021-07-29T14:59:56Z
dc.date.available2021-07-29T14:59:56Z
dc.date.issued2020-12
dc.description.abstractIn recent years, the emergence of antibiotic resistant pathogens made increasingly difficult to establish appropriate empiric antimicrobial therapy protocols for acute diabetic foot infection (DFI) treatment. Early recognition of the population at-risk for multidrug-resistant (MDR) bacterial infection is of paramount importance in order to decrease large-spectrum antibiotic overuse. This study used retrospective cohort study in a multidisciplinary tertiary diabetic foot unit. Patients with severe DFI were included and divided according to their infection resistance profile (susceptible vs MDR bacteria). Data regarding their comorbidities and length of hospital stay were collected. The primary endpoint was to determine the risk factors for MDR infections and to evaluate if these were associated with an increased length of stay (LOS). A total of 112 microbial isolates were included. Predominance of Gram-positive bacteria was observed and 22.3% of isolated bacteria were MDR. Previous hospitalisation was associated with a higher likelihood of MDR infection. MDR bacterial infection was also associated with an increased LOS (P = .0296). Our study showed a high incidence of MDR bacteria in patients with a DFI, especially in those who had a recent hospitalisation. MDR infections were associated with a prolonged LOS and represent a global public health issue for which emergent measures are needed.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationInt Wound J. 2020 Dec;17(6):1835-1839.pt_PT
dc.identifier.doi10.1111/iwj.13473pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3782
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectHSAC DERpt_PT
dc.subjectCHLC CIRpt_PT
dc.subjectCHLC PAT CLINpt_PT
dc.subjectHumanspt_PT
dc.subjectBacteriapt_PT
dc.subjectAnti-Bacterial Agents / pharmacologypt_PT
dc.subjectAnti-Bacterial Agents / therapeutic use
dc.subjectDiabetes Mellitus* / drug therapy
dc.subjectDiabetic Foot* / drug therapy
dc.subjectDiabetic Foot* / epidemiology
dc.subjectDrug Resistance, Multiple, Bacterial
dc.subjectGram-Negative Bacteria
dc.subjectMicrobial Sensitivity Tests
dc.subjectPortugal / epidemiology
dc.subjectRetrospective Studies
dc.titleMultidrug-Resistant Bacteria in Diabetic Foot Infections: Experience from a Portuguese Tertiary Centrept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1839pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage1835pt_PT
oaire.citation.titleInternational Wound Journalpt_PT
oaire.citation.volume17pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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