Publication
Hipotiroidismo Associado a Anticorpos Anti-Receptor da Hormona TSH com Ação Bloqueadora Determinada In Vitro
| dc.contributor.author | Marques, P | |
| dc.contributor.author | Chikh, K | |
| dc.contributor.author | Charrié, A | |
| dc.contributor.author | Pina, R | |
| dc.contributor.author | Bugalho, MJ | |
| dc.contributor.author | Lopes, L | |
| dc.date.accessioned | 2016-03-18T10:20:52Z | |
| dc.date.available | 2016-03-18T10:20:52Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Thyroid-stimulating hormone-receptor autoantibodies normally causes hyperthyroidism. However, they might have blocking activity causing hypothyroidism. A 11-year-old girl followed due to type 1 diabetes mellitus, celiac disease and euthyroid lymphocytic thyroiditis at diagnosis. Two years after the initial evaluation, thyroid-stimulating hormone was suppressed with normal free T4; nine months later, a biochemical evolution to hypothyroidism with thyroid-stimulating hormone-receptor autoantibodies elevation was seen; the patient remained always asymptomatic. Chinese hamster ovary cells were transfected with the recombinant human thyroid-stimulating hormone -receptor, and then exposed to the patient's serum; it was estimated a 'moderate' blocking activity of these thyroid-stimulating hormone-receptor autoantibodies, and concomitantly excluded stimulating action. In this case, the acknowledgment of the blocking activity of the serum thyroid-stimulating hormone-receptor autoantibodies, supported the hypothesis of a multifactorial aetiology of the hypothyroidism, which in the absence of the in vitro tests, we would consider only as a consequence of the destructive process associated to lymphocytic thyroiditis. | pt_PT |
| dc.identifier.citation | Acta Med Port 2015 Sep-Oct;28(5):663-666 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/2428 | |
| dc.language.iso | por | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Centro Editor Livreiro da Ordem dos Médicos | pt_PT |
| dc.subject | Hipotiroidismo | pt_PT |
| dc.subject | Doença de Graves | pt_PT |
| dc.subject | Receptores da Tireotropina | pt_PT |
| dc.subject | Tireoidite Autoimune | pt_PT |
| dc.subject | Criança | pt_PT |
| dc.subject | Caso Clínico | pt_PT |
| dc.subject | HDE END PED | pt_PT |
| dc.title | Hipotiroidismo Associado a Anticorpos Anti-Receptor da Hormona TSH com Ação Bloqueadora Determinada In Vitro | pt_PT |
| dc.title.alternative | Hypothyroidism Associated to TSH Hormone-Receptor Autoantibodies with Blocking Activity Assessed In Vitro | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 666 | pt_PT |
| oaire.citation.issue | 5 | pt_PT |
| oaire.citation.startPage | 663 | pt_PT |
| oaire.citation.volume | 28 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |