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Drug Provocation Tests to Betalactam Antibiotics: Experience in a Paediatric Setting
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Resumo(s)
Background: Few studies have been performed in children withs uspected betalactam
allergy.We aimed to assess the role of the drug provocation test(DPT)with betalactams in
a paediatric setting and to study the association between allergy to betalactam antibiotics and other allergic diseases.
Methods:We included all the patients under 15 years old who were consecutively referred
to the Immunoallergy Department, Dona Estefânia Hospital,Portugal(January 2002 to
April 2008)for a compatible history of allergic reaction to betalactam. All were submitted to a DPT.Children were proposed to performs kintests(ST)to betalactam antibiotics followed by DPT. If they decline ST,a DPT with the culprit drug was performed.
Results: We studied 161 children,60%were boys,with a median age of 5years old at the
time of the DPT.Thirty-three patients(20.5%)had an immediate reaction and 33(20.5%)a
non-immediate reaction. These verity of there porte dreactions was low in most cases.
Skin tests to betalactams were performed in 47 children and were positive in 8.DPT was
positive inonlyone(3.4%)of the patients skin tested and in 11(13.4%)of those not skin
tested. These verity of the DPT reaction was low.Asthma and food allergy were associated
with a positive DPT in the later group.
Conclusions: DPT seems a safe procedure even in the absence of ST in non-severe cases.
This could be a practical optionin infants and pre-school children,where ST are painful
and difficult to perform.Additional caution should be taken in children with asthma and
food allergy.
Descrição
Palavras-chave
Betalactam Penicilina Criança Hipersensibilidade HDE ALER
Contexto Educativo
Citação
Allergol Immunopathol(Madr).2010;38(6):300–306