Publication
Drug Provocation Tests to Betalactam Antibiotics: Experience in a Paediatric Setting
| dc.contributor.author | Chambel, M | |
| dc.contributor.author | Carreiro-Martins, P | |
| dc.contributor.author | Silva, I | |
| dc.contributor.author | Palma Carlos, S | |
| dc.contributor.author | Romeira, AM | |
| dc.contributor.author | Leiria-Pinto, P | |
| dc.date.accessioned | 2012-12-14T11:23:12Z | |
| dc.date.available | 2012-12-14T11:23:12Z | |
| dc.date.issued | 2010 | |
| dc.description.abstract | Background: Few studies have been performed in children withs uspected betalactam allergy.We aimed to assess the role of the drug provocation test(DPT)with betalactams in a paediatric setting and to study the association between allergy to betalactam antibiotics and other allergic diseases. Methods:We included all the patients under 15 years old who were consecutively referred to the Immunoallergy Department, Dona Estefânia Hospital,Portugal(January 2002 to April 2008)for a compatible history of allergic reaction to betalactam. All were submitted to a DPT.Children were proposed to performs kintests(ST)to betalactam antibiotics followed by DPT. If they decline ST,a DPT with the culprit drug was performed. Results: We studied 161 children,60%were boys,with a median age of 5years old at the time of the DPT.Thirty-three patients(20.5%)had an immediate reaction and 33(20.5%)a non-immediate reaction. These verity of there porte dreactions was low in most cases. Skin tests to betalactams were performed in 47 children and were positive in 8.DPT was positive inonlyone(3.4%)of the patients skin tested and in 11(13.4%)of those not skin tested. These verity of the DPT reaction was low.Asthma and food allergy were associated with a positive DPT in the later group. Conclusions: DPT seems a safe procedure even in the absence of ST in non-severe cases. This could be a practical optionin infants and pre-school children,where ST are painful and difficult to perform.Additional caution should be taken in children with asthma and food allergy. | por |
| dc.identifier.citation | Allergol Immunopathol(Madr).2010;38(6):300–306 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/881 | |
| dc.language.iso | eng | por |
| dc.publisher | Elsevier Espanã | por |
| dc.subject | Betalactam | por |
| dc.subject | Penicilina | por |
| dc.subject | Criança | por |
| dc.subject | Hipersensibilidade | por |
| dc.subject | HDE ALER | |
| dc.title | Drug Provocation Tests to Betalactam Antibiotics: Experience in a Paediatric Setting | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.conferencePlace | Espanha | por |
| oaire.citation.endPage | 306 | por |
| oaire.citation.startPage | 300 | por |
| oaire.citation.volume | 38 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |