Propylthiouracil Induced Pulmonary-Renal Syndrome: a Case Report.

Boattini, M; Rodrigues, A; Nascimento, P; Luz, KC; Castelo Branco, S; Rodrigues, N; Cachado, P; Garcia, T

http://hdl.handle.net/10400.17/2315

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Abstract(s)

Propylthiouracil (PTU) is known to induce antineutrophil cytoplasmatic antibody (ANCA) seropositivity; however, small vessel vasculitis (SVV) with pulmonary and renal involvement is rare. We present the case of an 81-year-old woman on PTU treatment due to toxic nodular goitre who developed alveolar hemorrhage and rapidly progressive glomerulonephritis. The authors highlight the importance of early recognising drug-induced pulmonary-renal syndrome (PRS) in order to avoid unnecessary tests, a delay in the diagnosis and evolution to end-stage kidney disease or life-threatening conditions.

Keywords

HSM MED HCC NEF Glomerulonephritis/chemically induced Hemorrhage/chemically induced Lung Diseases/chemically induced Propylthiouracil/adverse effects Aged, 80 and over