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Prognostic Value of Age Adjusted Segment Involvement Score As Measured by Coronary Computed Tomography: a Potential Marker of Vascular Age

2018-11Journal article Open access
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dc.contributor.authorAyoub, C
dc.contributor.authorKritharides, L
dc.contributor.authorYam, Y
dc.contributor.authorChen, L
dc.contributor.authorHossain, A
dc.contributor.authorAchenbach, S
dc.contributor.authorAl-Mallah, M
dc.contributor.authorAndreini, D
dc.contributor.authorBerman, D
dc.contributor.authorBudoff, M
dc.contributor.authorCademartiri, F
dc.contributor.authorCallister, T
dc.contributor.authorChang, HJ
dc.contributor.authorChinnaiyan, K
dc.contributor.authorCury, R
dc.contributor.authorDelago, A
dc.contributor.authorDunning, A
dc.contributor.authorFeuchtner, G
dc.contributor.authorGomez, M
dc.contributor.authorGransar, H
dc.contributor.authorHadamitzky, M
dc.contributor.authorHausleiter, J
dc.contributor.authorHindoyan, N
dc.contributor.authorKaufmann, P
dc.contributor.authorKim, YJ
dc.contributor.authorLeipsic, J
dc.contributor.authorMaffei, E
dc.contributor.authorMarques, H
dc.contributor.authorPontone, G
dc.contributor.authorRaff, G
dc.contributor.authorRubinshtein, R
dc.contributor.authorShaw, L
dc.contributor.authorVillines, T
dc.contributor.authorMin, J
dc.contributor.authorChow, B
dc.date.accessioned2019-11-26T16:10:11Z
dc.date.available2019-11-26T16:10:11Z
dc.date.issued2018-11
dc.description.abstractExtent of coronary atherosclerotic disease (CAD) burden on coronary computed tomography angiography (CCTA) as measured by segment involvement score (SIS) has a prognostic value. We sought to investigate the incremental prognostic value of 'age adjusted SIS' (aSIS), which may be a marker of premature atherosclerosis and vascular age. Consecutive patients were prospectively enrolled into the CONFIRM (Coronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicentre) multinational observational study. Patients were followed for the outcome of all-cause death. aSIS was calculated on CCTA for each patient, and its incremental prognostic value was evaluated. A total of 22,211 patients [mean age 58.5 ± 12.7 years, 55.8% male) with a median follow-up of 27.3 months (IQR 17.8, 35.4)] were identified. After adjustment for clinical factors and presence of obstructive CAD, higher aSIS was associated with increased death on multivariable analysis, with hazard ratio (HR) 2.40 (1.83-3.16, p < 0.001), C-statistic 0.723 (0.700-0.756), net reclassification improvement (NRI) 0.36 (0.26-0.47, p < 0.001), and relative integrated discrimination improvement (IDI) 0.33 (p = 0.009). aSIS had HR 3.48 (2.33-5.18, p < 0.001) for mortality in those without obstructive CAD, compared to HR 1.79 (1.25-2.58, p = 0.02) in those with obstructive CAD. In conclusion, aSIS has an incremental prognostic value to traditional risk factors and obstructive CAD, and may enhance CCTA risk stratification.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationHeart Vessels. 2018 Nov;33(11):1288-1300.pt_PT
dc.identifier.doi10.1007/s00380-018-1188-3pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3367
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.subjectAge Factorspt_PT
dc.subjectAgedpt_PT
dc.subjectAgingpt_PT
dc.subjectComputed Tomography Angiographypt_PT
dc.subjectCoronary Angiographypt_PT
dc.subjectCoronary Artery Diseasept_PT
dc.subjectCoronary Vesselspt_PT
dc.subjectFemalept_PT
dc.subjectFollow-Up Studiespt_PT
dc.subjectHumanspt_PT
dc.subjectMalept_PT
dc.subjectMiddle Agedpt_PT
dc.subjectPlaque, Atheroscleroticpt_PT
dc.subjectPredictive Value of Testspt_PT
dc.subjectPrognosispt_PT
dc.subjectProspective Studiespt_PT
dc.subjectRisk Factorspt_PT
dc.subjectTime Factorspt_PT
dc.subjectRegistriespt_PT
dc.subjectHCC CIRpt_PT
dc.titlePrognostic Value of Age Adjusted Segment Involvement Score As Measured by Coronary Computed Tomography: a Potential Marker of Vascular Agept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1300pt_PT
oaire.citation.issue11pt_PT
oaire.citation.startPage1288pt_PT
oaire.citation.titleHeart and Vesselspt_PT
oaire.citation.volume33pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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