Publication
New Onset Nephrotic - Range Proteinuria in a Patient with Chronic Kidney Disease - Not Always What it Seems
| dc.contributor.author | Cardoso Fernandes, S | |
| dc.contributor.author | Góis, M | |
| dc.contributor.author | Viana, H | |
| dc.contributor.author | Ferreira, AC | |
| dc.date.accessioned | 2024-08-13T11:07:36Z | |
| dc.date.available | 2024-08-13T11:07:36Z | |
| dc.date.issued | 2023 | |
| dc.description.abstract | Light chain deposition disease (LCDD) is a rare condition that is characterized by the deposition of monoclonal immunoglobulin light chains in glomerular and tubular basement membranes. We report the case of a 72-yearold male with long-standing and stable chronic kidney disease (CKD) presumably due to hypertension and lithiasis who presented with new-onset nephrotic range proteinuria, anemia and rapidly worsening renal function that eventually led to end-stage renal disease (ESRD) requiring dialysis. Radiologic and laboratory workup found enlarged kidneys in the ultrasound and increased kappa/ lambda ratio (KLR) suggestive of a plasma cell dyscrasia. The patient underwent bone marrow biopsy, confirming the diagnosis of kappa light chains multiple myeloma (MM). Since exclusion of amyloidosis was essential for determining therapeutic strategies, a kidney biopsy was performed, showing deposition of Periodic acid-Schiff (PAS) positive and silver-negative material in the glomeruli, tubular basement membrane, vessels and interstitium and kappa light chain restriction in the immunofluorescence staining. A diagnosis of kappa LCDD secondary to MM was made, and the patient received a Bortezomib-based regimen directed to the plasma cell disorder. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | J Clin Nephrol Ren Care 2023, 9 (1):085 | pt_PT |
| dc.identifier.doi | 10.23937/2572-3286.1510085 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/4987 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | ClinMed International Library | pt_PT |
| dc.subject | Monoclonal immunoglobulin | pt_PT |
| dc.subject | Nephrotic proteinuria | pt_PT |
| dc.subject | Nodular glomerulosclerosis | pt_PT |
| dc.subject | Chronic kidney disease | pt_PT |
| dc.subject | Light chain deposition disease | pt_PT |
| dc.subject | Case Report | pt_PT |
| dc.subject | HCC NEF | pt_PT |
| dc.title | New Onset Nephrotic - Range Proteinuria in a Patient with Chronic Kidney Disease - Not Always What it Seems | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | pt_PT |
| oaire.citation.startPage | 085 | pt_PT |
| oaire.citation.volume | 9 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |