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Publication
TINU syndrome – Two Clinical Cases of Tubulo-Interstitial Nephritis and Uveitis
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Authors
Advisor(s)
Abstract(s)
TINU (Tubulo-Interstitial Nephritis and Uveitis)syndrome is a rare disease of unknown aetiology characterised by the association between interstitial nephritis and uveitis. The authors present the cases of two young children whose symptoms began with anorexia and weight loss, associated with renal failure and proteinuria of tubular origin. One child also presented anaemia, glycosuria without hyperglycaemia
and microhaematuria. A few months later both
developed uveitis. In both cases the renal biopsy showed changes compatible with interstitial nephritis.
As interstitial nephritis and uveitis aetiologies were not identified, TINU syndrome was suggested as a possible diagnosis. In both children there was a
complete resolution, with one needing systemic steroids and immunosuppressive treatment.
TINU syndrome should always be considered in
the differential diagnosis of patients with renal and ophthalmologic changes.
Description
Keywords
Nefrite Intersticial Uveíte Criança Caso Clínico HDE NEF PED
Citation
Port J Nephrol Hypert 2008; 22 (3): 263-266