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Pustulose Generalizada Exantemática Aguda Associada ao Diltiazem

dc.contributor.authorSerrão, V
dc.contributor.authorCaldas Lopes, L
dc.contributor.authorCampos Lopes, JM
dc.contributor.authorLobo, L
dc.contributor.authorFerreira, A
dc.date.accessioned2011-04-15T16:10:56Z
dc.date.available2011-04-15T16:10:56Z
dc.date.issued2008
dc.description.abstractAcute generalized exanthematous pustulosis (AGEP) usually presents with the acute appearance of oedematous and erythematous lesions, on which multiple sterile pustules appear, associated with fever. Almost 90% of cases are associated with drugs, with antibiotics (penicillins and macrolides) being the most frequent causative agents. We describe a 36-year-old female patient, which started diltiazem 120mg/day for hypertension. After 6 days of therapy, multiple erythematous and oedematous lesions appeared, with associated multiple small non-follicular pustules. Oral corticosteroids were started, with progressive and complete improvement. Patch-tests were performed, which revealed positivity for diltiazem. Although a rare entity, AGEP must be considered in cases of acute eruptions with disseminated pustules and fever. The use of patch tests in this disease may be useful as positive reactions are frequent.
dc.identifier.citationActa Med Port. 2008 Jan-Feb;21(1):99-102por
dc.identifier.urihttp://hdl.handle.net/10400.17/141
dc.language.isoporpor
dc.publisherCentro Editor e Livreiro da Ordem dos Médicospor
dc.subjectAdultopor
dc.subjectErupções por Medicamentopor
dc.subjectEfeitos Adversospor
dc.subjectDiltiazempor
dc.subjectDoenças da Pelepor
dc.subjectExantemapor
dc.titlePustulose Generalizada Exantemática Aguda Associada ao Diltiazempor
dc.title.alternativeAcute Generalized Exanthematous Pustulosis Associated with Diltiazempor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage102por
oaire.citation.startPage99por
oaire.citation.titleActa Médica Portuguesapor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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