Sickle cell anemia - Nitric oxide related genetic modifiers of hematological and biochemical parameters

Sickle cell anemia (SCA) is an inherited blood disorder. SCA patients present clinical and hematologic variability that cannot be only explained by the single mutation in the beta-globin gene. Others genetic modifiers and environmental effects are important for the clinical phenotype. SCA patients present arginine deficiency that contributes to a lower nitric oxide (NO) bioactivity.

Keywords

Adolescent Adult Anemia, Sickle Cell Child Child, Preschool Female Humans Male Nitric Oxide Polymorphism, Genetic Quality of Life Young Adult HDE HEM PED HDE GEN