Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis

Ferrão, J; Sardinha, M; Dutra, E

http://hdl.handle.net/10400.17/4641

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Authors

Ferrão, J

Sardinha, M

Dutra, E

Abstract(s)

Hematological paraneoplastic syndromes are fairly uncommon. While mild leukocytosis in solid tumors is well reported, white blood cell (WBC) count over 50,000 u/L, described as paraneoplastic leukemoid reaction (PLR), is not. Indeed, when found, it is usually associated with a higher burden of disease, tumor activity and worse clinical outcomes. We report the case of a challenging and burdensome diagnosis of a presumptive hematological paraneoplastic syndrome in a patient with a locally advanced lung cancer admitted in the Internal Medicine ward. After the end of chemotherapy, clinical and laboratory benefit was observed; however, the aggressive course of the disease became clear, with progression and downhill course that was unresponsive to treatment.

Keywords

CHLC MED HSAC ONC CHLC ANPAT Antineoplastic Agents / therapeutic use Carcinoma / complications* Carcinoma / drug therapy Fatal Outcome Humans Male Middle Aged Lung Neoplasms / complications* Lung Neoplasms / drug therapy Paraneoplastic Syndromes / diagnosis* Paraneoplastic Syndromes / pathology* Prognosis