Publication
Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis
| dc.contributor.author | Ferrão, J | |
| dc.contributor.author | Sardinha, M | |
| dc.contributor.author | Dutra, E | |
| dc.date.accessioned | 2023-08-11T14:44:26Z | |
| dc.date.available | 2023-08-11T14:44:26Z | |
| dc.date.issued | 2021-08 | |
| dc.description.abstract | Hematological paraneoplastic syndromes are fairly uncommon. While mild leukocytosis in solid tumors is well reported, white blood cell (WBC) count over 50,000 u/L, described as paraneoplastic leukemoid reaction (PLR), is not. Indeed, when found, it is usually associated with a higher burden of disease, tumor activity and worse clinical outcomes. We report the case of a challenging and burdensome diagnosis of a presumptive hematological paraneoplastic syndrome in a patient with a locally advanced lung cancer admitted in the Internal Medicine ward. After the end of chemotherapy, clinical and laboratory benefit was observed; however, the aggressive course of the disease became clear, with progression and downhill course that was unresponsive to treatment. | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.citation | Am J Med Sci . 2021 Aug;362(2):211-214 | pt_PT |
| dc.identifier.doi | 10.1016/j.amjms.2021.01.027 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/4641 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Elsevier | pt_PT |
| dc.subject | CHLC MED | pt_PT |
| dc.subject | HSAC ONC | pt_PT |
| dc.subject | CHLC ANPAT | pt_PT |
| dc.subject | Antineoplastic Agents / therapeutic use | pt_PT |
| dc.subject | Carcinoma / complications* | pt_PT |
| dc.subject | Carcinoma / drug therapy | pt_PT |
| dc.subject | Fatal Outcome | pt_PT |
| dc.subject | Humans | pt_PT |
| dc.subject | Male | pt_PT |
| dc.subject | Middle Aged | pt_PT |
| dc.subject | Lung Neoplasms / complications* | pt_PT |
| dc.subject | Lung Neoplasms / drug therapy | pt_PT |
| dc.subject | Paraneoplastic Syndromes / diagnosis* | pt_PT |
| dc.subject | Paraneoplastic Syndromes / pathology* | pt_PT |
| dc.subject | Prognosis | pt_PT |
| dc.title | Hyperleukocytosis in Solid Tumors: a Rare Paraneoplastic Syndrome Associated with Poor Prognosis | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 214 | pt_PT |
| oaire.citation.issue | 2 | pt_PT |
| oaire.citation.startPage | 211 | pt_PT |
| oaire.citation.title | The American Journal of the Medical Sciences | pt_PT |
| oaire.citation.volume | 362 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |