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Rhinitis Associated with Asthma is Distinct from Rhinitis Alone: The ARIA‐MeDALL Hypothesis

2023Journal article Open access
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dc.contributor.authorBousquet, J
dc.contributor.authorMelén, E
dc.contributor.authorHaahtela, T
dc.contributor.authorKoppelman, GH
dc.contributor.authorTogias, A
dc.contributor.authorValenta, R
dc.contributor.authorAkdis, CA
dc.contributor.authorCzarlewski, W
dc.contributor.authorRothenberg, M
dc.contributor.authorValiulis, A
dc.contributor.authorWickman, M
dc.contributor.authorAkdis, M
dc.contributor.authorAguilar, D
dc.contributor.authorBedbrook, A
dc.contributor.authorBindslev‐Jensen, C
dc.contributor.authorBosnic‐Anticevich, S
dc.contributor.authorBoulet, LP
dc.contributor.authorBrightling, CE
dc.contributor.authorBrussino, L
dc.contributor.authorBurte, E
dc.contributor.authorBustamante, M
dc.contributor.authorCanonica, GW
dc.contributor.authorCecchi, L
dc.contributor.authorCeledon, JC
dc.contributor.authorChaves Loureiro, C
dc.contributor.authorCosta, E
dc.contributor.authorCruz, AA
dc.contributor.authorErhola, M
dc.contributor.authorGemicioglu, B
dc.contributor.authorFokkens, WJ
dc.contributor.authorGarcia‐Aymerich, J
dc.contributor.authorGuerra, S
dc.contributor.authorHeinrich, J
dc.contributor.authorIvancevich, JC
dc.contributor.authorKeil, T
dc.contributor.authorKlimek, L
dc.contributor.authorKuna, P
dc.contributor.authorKupczyk, M
dc.contributor.authorKvedariene, V
dc.contributor.authorLarenas‐Linnemann, DE
dc.contributor.authorLemonnier, N
dc.contributor.authorLodrup Carlsen, KC
dc.contributor.authorLouis, R
dc.contributor.authorMakela, M
dc.contributor.authorMakris, M
dc.contributor.authorMaurer, M
dc.contributor.authorMomas, I
dc.contributor.authorMorais‐Almeida, M
dc.contributor.authorMullol, J.
dc.contributor.authorNaclerio, RN
dc.contributor.authorNadeau, K
dc.contributor.authorNadif, R
dc.contributor.authorNiedoszytko, M
dc.contributor.authorOkamoto, Y
dc.contributor.authorOllert, M
dc.contributor.authorPapadopoulos, NG
dc.contributor.authorPassalacqua, G
dc.contributor.authorPatella, V
dc.contributor.authorPawankar, R
dc.contributor.authorPham‐Thi, N
dc.contributor.authorPfaar, O
dc.contributor.authorRegateiro, FS
dc.contributor.authorRing, J
dc.contributor.authorRouadi, PW
dc.contributor.authorSamolinski, B
dc.contributor.authorSastre, J
dc.contributor.authorSavouré, M
dc.contributor.authorScichilone, N
dc.contributor.authorShamji, MH
dc.contributor.authorSheikh, A
dc.contributor.authorSiroux, V
dc.contributor.authorSousa‐Pinto, B
dc.contributor.authorStandl, M
dc.contributor.authorSunyer, J
dc.contributor.authorTaborda‐Barata, L
dc.contributor.authorToppila‐Salmi, S
dc.contributor.authorTorres, MJ
dc.contributor.authorTsiligianni, I
dc.contributor.authorValovirta, E
dc.contributor.authorVandenplas, O
dc.contributor.authorVentura, MT
dc.contributor.authorWeiss, S
dc.contributor.authorYorgancioglu, A
dc.contributor.authorZhang, L
dc.contributor.authorAbdul Latiff, AH
dc.contributor.authorAberer, W
dc.contributor.authorAgache, I
dc.contributor.authorAl‐Ahmad, M
dc.contributor.authorAlobid, I
dc.contributor.authorAnsotegui, IJ
dc.contributor.authorArshad, SH
dc.contributor.authorAsayag, E
dc.contributor.authorBarbara, C
dc.contributor.authorBaharudin, A
dc.contributor.authorBattur, L
dc.contributor.authorBennoor, KS
dc.contributor.authorBerghea, EC
dc.contributor.authorBergmann, KC
dc.contributor.authorBernstein, D
dc.contributor.authorBewick, M
dc.contributor.authorBlain, H
dc.contributor.authorBonini, M
dc.contributor.authorBraido, F
dc.contributor.authorBuhl, R
dc.contributor.authorBumbacea, RS
dc.contributor.authorBush, A
dc.contributor.authorCalderon, M
dc.contributor.authorCalvo‐Gil, M
dc.contributor.authorCamargos, P
dc.contributor.authorCaraballo, L
dc.contributor.authorCardona, V
dc.contributor.authorCarr, W
dc.contributor.authorCarreiro‐Martins, P
dc.contributor.authorCasale, T
dc.contributor.authorCepeda Sarabia, AM
dc.contributor.authorChandrasekharan, R
dc.contributor.authorCharpin, D
dc.contributor.authorChen, YZ
dc.contributor.authorCherrez‐Ojeda, I
dc.contributor.authorChivato, T
dc.contributor.authorChkhartishvili, E
dc.contributor.authorChristoff, G
dc.contributor.authorChu, DK
dc.contributor.authorCingi, C
dc.contributor.authorCorreia de Sousa, J
dc.contributor.authorCorrigan, C
dc.contributor.authorCustovic, A
dc.contributor.authorD’Amato, G
dc.contributor.authorDel Giacco, S
dc.contributor.authorDe Blay, F
dc.contributor.authorDevillier, P
dc.contributor.authorDidier, A
dc.contributor.authordo Ceu Teixeira, M
dc.contributor.authorDokic, D
dc.contributor.authorDouagui, H
dc.contributor.authorDoulaptsi, M
dc.contributor.authorDurham, S
dc.contributor.authorDykewicz, M
dc.contributor.authorEiwegger, T
dc.contributor.authorEl‐Sayed, ZA
dc.contributor.authorEmuzyte, R
dc.contributor.authorFiocchi, A
dc.contributor.authorFyhrquist, N
dc.contributor.authorGomez, RM
dc.contributor.authorGotua, M
dc.contributor.authorGuzman, MA
dc.contributor.authorHagemann, J
dc.contributor.authorHamamah, S
dc.contributor.authorHalken, S
dc.contributor.authorHalpin, DMG
dc.contributor.authorHofmann, M
dc.contributor.authorHossny, E
dc.contributor.authorHrubiško, M
dc.contributor.authorIrani, C
dc.contributor.authorIspayeva, Z
dc.contributor.authorJares, E
dc.contributor.authorJartti, T
dc.contributor.authorJassem, E
dc.contributor.authorJulge, K
dc.contributor.authorJust, J
dc.contributor.authorJutel, M
dc.contributor.authorKaidashev, I
dc.contributor.authorKalayci, O
dc.contributor.authorKalyoncu, AF
dc.contributor.authorKardas, P
dc.contributor.authorKirenga, B
dc.contributor.authorKraxner, H
dc.contributor.authorKull, I
dc.contributor.authorKulus, M
dc.contributor.authorLa Grutta, S
dc.contributor.authorLau, S
dc.contributor.authorLe Tuyet Thi, L
dc.contributor.authorLevin, M
dc.contributor.authorLipworth, B
dc.contributor.authorLourenço, O
dc.contributor.authorMahboub, B
dc.contributor.authorMartinez‐Infante, E
dc.contributor.authorMatricardi, P
dc.contributor.authorMiculinic, N
dc.contributor.authorMigueres, N
dc.contributor.authorMihaltan, F
dc.contributor.authorMohammad, Y
dc.contributor.authorMoniuszko, M
dc.contributor.authorMontefort, S
dc.contributor.authorNeffen, H
dc.contributor.authorNekam, K
dc.contributor.authorNunes, E
dc.contributor.authorNyembue Tshipukane, D
dc.contributor.authorO’Hehir, R
dc.contributor.authorOgulur, I
dc.contributor.authorOhta, K
dc.contributor.authorOkubo, K
dc.contributor.authorOuedraogo, S
dc.contributor.authorOlze, H
dc.contributor.authorPali‐Schöll, I
dc.contributor.authorPalomares, O
dc.contributor.authorPalosuo, K
dc.contributor.authorPanaitescu, C
dc.contributor.authorPanzner, P
dc.contributor.authorPark, HS
dc.contributor.authorPitsios, C
dc.contributor.authorPlavec, D
dc.contributor.authorPopov, TA
dc.contributor.authorPuggioni, F
dc.contributor.authorQuirce, S
dc.contributor.authorRecto, M
dc.contributor.authorRepka‐Ramirez, MS
dc.contributor.authorRobalo Cordeiro, C
dc.contributor.authorRoche, N
dc.contributor.authorRodriguez‐Gonzalez, M
dc.contributor.authorRomantowski, J
dc.contributor.authorRosario Filho, N
dc.contributor.authorRottem, M
dc.contributor.authorSagara, H
dc.contributor.authorSerpa, FS
dc.contributor.authorSayah, Z
dc.contributor.authorScheire, S
dc.contributor.authorSchmid‐Grendelmeier, P
dc.contributor.authorSisul, JC
dc.contributor.authorSole, D
dc.contributor.authorSoto‐Martinez, M
dc.contributor.authorSova, M
dc.contributor.authorSperl, A
dc.contributor.authorSpranger, O
dc.contributor.authorStelmach, R
dc.contributor.authorSuppli Ulrik, C
dc.contributor.authorThomas, M
dc.contributor.authorTo, T
dc.contributor.authorTodo‐Bom, A
dc.contributor.authorTomazic, PV
dc.contributor.authorUrrutia‐Pereira, M
dc.contributor.authorValentin‐Rostan, M
dc.contributor.authorVan Ganse, E
dc.contributor.authorvan Hage, M
dc.contributor.authorVasankari, T
dc.contributor.authorVichyanond, P
dc.contributor.authorViegi, G
dc.contributor.authorWallace, D
dc.contributor.authorWang, DY
dc.contributor.authorWilliams, S
dc.contributor.authorWorm, M
dc.contributor.authorYiallouros, P
dc.contributor.authorYusuf, O
dc.contributor.authorZaitoun, F
dc.contributor.authorZernotti, M
dc.contributor.authorZidarn, M
dc.contributor.authorZuberbier, J
dc.contributor.authorFonseca, JA
dc.contributor.authorZuberbier, T
dc.contributor.authorAnto, JM
dc.date.accessioned2023-05-22T11:53:44Z
dc.date.available2023-05-22T11:53:44Z
dc.date.issued2023
dc.description.abstractAsthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of "one-airway-one-disease," coined over 20 years ago, is a simplistic approach of the links between upper- and lower-airway allergic diseases. With new data, it is time to reassess the concept. This article reviews (i) the clinical observations that led to Allergic Rhinitis and its Impact on Asthma (ARIA), (ii) new insights into polysensitization and multimorbidity, (iii) advances in mHealth for novel phenotype definitions, (iv) confirmation in canonical epidemiologic studies, (v) genomic findings, (vi) treatment approaches, and (vii) novel concepts on the onset of rhinitis and multimorbidity. One recent concept, bringing together upper- and lower-airway allergic diseases with skin, gut, and neuropsychiatric multimorbidities, is the "Epithelial Barrier Hypothesis." This review determined that the "one-airway-one-disease" concept does not always hold true and that several phenotypes of disease can be defined. These phenotypes include an extreme "allergic" (asthma) phenotype combining asthma, rhinitis, and conjunctivitis. Rhinitis alone and rhinitis and asthma multimorbidity represent two distinct diseases with the following differences: (i) genomic and transcriptomic background (Toll-Like Receptors and IL-17 for rhinitis alone as a local disease; IL-33 and IL-5 for allergic and non-allergic multimorbidity as a systemic disease), (ii) allergen sensitization patterns (mono- or pauci-sensitization versus polysensitization), (iii) severity of symptoms, and (iv) treatment response. In conclusion, rhinitis alone (local disease) and rhinitis with asthma multimorbidity (systemic disease) should be considered as two distinct diseases, possibly modulated by the microbiome, and may be a model for understanding the epidemics of chronic and autoimmune diseases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationAllergy . 2023 May;78(5):1169-1203pt_PT
dc.identifier.doi10.1111/all.15679pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4524
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectAllergenspt_PT
dc.subjectAsthma* / diagnosispt_PT
dc.subjectAsthma* / epidemiologypt_PT
dc.subjectAsthma* / etiologypt_PT
dc.subjectMultimorbiditypt_PT
dc.subjectHumanspt_PT
dc.subjectRhinitis* / complicationspt_PT
dc.subjectRhinitis* / diagnosispt_PT
dc.subjectRhinitis* / epidemiologypt_PT
dc.subjectRhinitis, Allergic* / complicationspt_PT
dc.subjectHDE ALERpt_PT
dc.titleRhinitis Associated with Asthma is Distinct from Rhinitis Alone: The ARIA‐MeDALL Hypothesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1203pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage1169pt_PT
oaire.citation.titleAllergypt_PT
oaire.citation.volume78pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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