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Stratification of ST-Elevation Myocardial Infarction Patients Based on Soluble CD40L Longitudinal Changes

2016-10Journal article Open access
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dc.contributor.authorNapoleão, P
dc.contributor.authorCabral, L
dc.contributor.authorSelas, M
dc.contributor.authorFreixo, C
dc.contributor.authorMonteiro, MC
dc.contributor.authorCriado, MB
dc.contributor.authorCosta, M
dc.contributor.authorEnguita, F
dc.contributor.authorViegas-Crespo, AM
dc.contributor.authorSaldanha, C
dc.contributor.authorMota Carmo, M
dc.contributor.authorCruz Ferreira, R
dc.contributor.authorPinheiro, T
dc.date.accessioned2017-06-30T15:33:35Z
dc.date.available2017-06-30T15:33:35Z
dc.date.issued2016-10
dc.description.abstractInvolvement of soluble CD40 ligand (sCD40L) in thrombosis and inflammation on the context of coronary artery disease is currently being revised. In that perspective, we had studied the association of sCD40L with markers of platelet activation and markers of endothelial and vascular function. On that cohort, a stratification of patients with acute myocardial infarction (AMI) 1 month after percutaneous coronary intervention (PCI) was observed based on concentrations of sCD40L. The study intended to identify the groups of AMI patients with different profiles of sCD40L concentrations and verify how medication, clinical evolution, biochemical data, and markers of regulation of endothelial function at genetic (endothelial nitric oxide synthase polymorphisms) and post-transcriptional levels (circulating microRNAs) affect sCD40L serum levels. Lower quartiles of sCD40L (<2.3 ng/mL) were associated with higher concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP), high frequency of G894T polymorphism, and altered expression of a set of microRNAs assumed to be involved in the regulation of endothelial and cardiac function and myocardium hypertrophy, relative to patients in sCD40L upper quartiles. A characteristic sCD40L variation pattern in STEMI patients was identified. Low levels of sCD40L 1 month after PCI distinguish STEMI patients with worse prognosis, a compromised cardiac healing, and a persistent endothelial dysfunction, as given by the association between sCD40L, NT-proBNP, G894T polymorphism, and specific profile of miRNA expression. These results suggest sCD40L could have a prognostic value in STEMI patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationTransl Res. 2016 Oct;176:95-104pt_PT
dc.identifier.doi10.1016/j.trsl.2016.04.005pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2719
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationSFRM/BPD/6308/2009pt_PT
dc.relationInstitute for Bioengineering and Biosciences
dc.subjectAgedpt_PT
dc.subjectCD40 Ligandpt_PT
dc.subjectCase-Control Studiespt_PT
dc.subjectFemalept_PT
dc.subjectGene Expression Profilingpt_PT
dc.subjectGenotypept_PT
dc.subjectHumanspt_PT
dc.subjectLongitudinal Studiespt_PT
dc.subjectMalept_PT
dc.subjectMicroRNAspt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMyocardial Infarctionpt_PT
dc.subjectNatriuretic Peptide, Brainpt_PT
dc.subjectNitric Oxide Synthase Type IIIpt_PT
dc.subjectPeptide Fragmentspt_PT
dc.subjectPercutaneous Coronary Interventionpt_PT
dc.subjectSolubilitypt_PT
dc.subjectElectrocardiographypt_PT
dc.subjectHSM CARpt_PT
dc.titleStratification of ST-Elevation Myocardial Infarction Patients Based on Soluble CD40L Longitudinal Changespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleInstitute for Bioengineering and Biosciences
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UID%2FBIO%2F04565%2F2013/PT
oaire.citation.endPage104pt_PT
oaire.citation.startPage95pt_PT
oaire.citation.titleTranslational Research, The Journal of Laboratory and Clinical Medicinept_PT
oaire.citation.volume176pt_PT
oaire.fundingStream6817 - DCRRNI ID
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication9c61da7d-b93b-4eef-92fd-793d3550cee4
relation.isProjectOfPublication.latestForDiscovery9c61da7d-b93b-4eef-92fd-793d3550cee4

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