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One Year of Lamivudine Therapy for Portuguese Patients with Chronic Hepatitis B

2003Journal article Open access
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dc.contributor.authorAreias, J
dc.contributor.authorCalinas, F
dc.contributor.authorPorto, A
dc.contributor.authorCarvalho, A
dc.contributor.authorFreitas, D
dc.contributor.authorMacedo, G
dc.contributor.authorNoronha, R
dc.contributor.authorCotter, J
dc.contributor.authorMeliço-Silvestre, A
dc.contributor.authorPeixe, R
dc.contributor.authorPratas, J
dc.contributor.authorBarrote, D
dc.contributor.authorTeixeira, R
dc.contributor.authorAugusto, F
dc.contributor.authorCarrilho, I
dc.contributor.authorCampante, F
dc.contributor.authorVelosa, J
dc.contributor.authorCarvalho, L
dc.contributor.authorDuarte, MA
dc.contributor.authorGuerreiro, H
dc.contributor.authorPires, C
dc.contributor.authorSilva, A
dc.contributor.authorCotrim, I
dc.contributor.authorGuedes, F
dc.contributor.authorTomé, L
dc.contributor.authorMarcelino, M
dc.contributor.authorGonçalves, C
dc.contributor.authorFerreira, E
dc.contributor.authorMatos, L
dc.contributor.authorPeixe, P
dc.contributor.authorEsteves, J
dc.contributor.authorValente, T
dc.contributor.authorSimões, C
dc.contributor.authorMarinho, C
dc.contributor.authorJasmins, L
dc.contributor.authorVieira, MJ
dc.contributor.authorMarinho, R
dc.contributor.authorMatos, P
dc.contributor.authorEstevens, J
dc.contributor.authorCarrasquinho, J
dc.contributor.authorSalcedo, G
dc.contributor.authorParada, P
dc.contributor.authorTeixeira, C
dc.date.accessioned2017-04-19T14:33:13Z
dc.date.available2017-04-19T14:33:13Z
dc.date.issued2003
dc.description.abstractOBJECTIVE: To assess the efficacy of lamivudine treatment on hepatitis B e antigen (HBeAg) and/or hepatitis B surface antigen (HBsAg) seroconversion, on other virological and serological markers of response including hepatitis B virus (HBV) DNA and serum aminotransferases, and the safety of lamivudine treatment in hepatitis B patients. PATIENTS: This phase III open-label study evaluated the virological and biochemical response to lamivudine in 70 Portuguese patients with HBeAg positive chronic hepatitis B. Patients were treated with lamivudine 100mg once daily for 12 months. METHODS: Antiviral activity was assessed by measuring alanine aminotransferase (ALT)/aspartate aminotransferase (AST) levels at all protocol visits, and hepatitis B serology and HBV DNA were performed at baseline and at month 12 visits. Evaluation of safety and tolerance was based on clinical adverse events and laboratory analyses. RESULTS: The primary endpoint was virological response at month 12, defined as loss of detectable HBeAg from serum with a reduction of HBV DNA to undetectable levels, and this was observed in 19/69 (27.5%) of patients. Almost half of the patients were HBV DNA negative by this time. Mean ALT values decreased steadily during treatment and by 12 months 61% of patients had values within the normal range. HBeAg seroconversion (HBeAg negative, HBeAb positive) was achieved in 27.9% of patients by 12 months, although all patients remained HBsAg positive. CONCLUSION: Lamivudine was well tolerated and the incidence of adverse events was similar to those reported in previous studies. Lamivudine treatment resulted in virological and biochemical improvements in HBeAg positive chronic hepatitis B patients, with HBeAg seroconversion in one-third of patients.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Drug Investig. 2003;23(5):339-46pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/2677
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAdis Data Informationpt_PT
dc.subjectHSAC GASpt_PT
dc.subjectChronic Hepatitis Bpt_PT
dc.subjectLamivudinept_PT
dc.subjectPortugalpt_PT
dc.subjectTherapypt_PT
dc.titleOne Year of Lamivudine Therapy for Portuguese Patients with Chronic Hepatitis Bpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage346pt_PT
oaire.citation.issue5pt_PT
oaire.citation.startPage339pt_PT
oaire.citation.titleClinical Drug Investigationpt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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