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In Healthy Subjects Nasal Nitric Oxide Does Not Correlate with Olfactory Sensitivity, Trigeminal Sensitivity, and Nasal Airflow

2021Journal article Open access
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dc.contributor.authorMariano, M
dc.contributor.authorDrews, T
dc.contributor.authorHummel, T
dc.date.accessioned2022-05-20T14:56:56Z
dc.date.available2022-05-20T14:56:56Z
dc.date.issued2021
dc.description.abstractObjective: The aim of the study was to determine the relationship between nasal nitric oxide (nNO) and olfactory sensitivity, trigeminal sensitivity and nasal airflow in healthy subjects. Study design: This is a correlational study. Setting: This study was carried out in a tertiary referral centre. Participants: Forty healthy participants were recruited. Main outcome measures: nNO was measured using a chemiluminescence analyser (Niox Vero® , Circassia AB, Uppsala, Sweden), olfactory sensitivity was determined using phenyl ethyl alcohol odour thresholds using the 'Sniffin' Sticks', trigeminal sensitivity was assessed with carbon dioxide delivered by an automated device, and nasal airflow was measured using the peak nasal inspiratory flow (PNIF). Results: The median nNO was 518 ppb (IQR =333) in the right nostril, and it was 567 ppb (IQR = 314) in the left nostril. The median odour threshold was 7.1 (IQR = 4.4), the median CO2 threshold was 919 ms (IQR = 1297) and the mean PNIF was 108 L/min (SEM = 4.9). nNO did not correlate significantly with odour threshold, CO2 threshold or PNIF (Spearman's |ρ| <0.15, p > .18). Conclusion: In healthy subjects, nNO does not appear to be associated with olfactory sensitivity, trigeminal sensitivity and PNIF.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationClin Otolaryngol. 2021 Nov;46(6):1339-1344.pt_PT
dc.identifier.doi10.1111/coa.13845.pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4089
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherWileypt_PT
dc.subjectCHLC ORLpt_PT
dc.subjectAdultpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectHumanspt_PT
dc.subjectAdministration, Intranasal*pt_PT
dc.subjectHealthy Volunteerspt_PT
dc.subjectNitric Oxide / administration & dosage*pt_PT
dc.subjectSmell / drug effects*pt_PT
dc.subjectYoung Adultpt_PT
dc.subjectTrigeminal Nerve / drug effects*pt_PT
dc.titleIn Healthy Subjects Nasal Nitric Oxide Does Not Correlate with Olfactory Sensitivity, Trigeminal Sensitivity, and Nasal Airflowpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage1344pt_PT
oaire.citation.startPage1339pt_PT
oaire.citation.titleClinical Otolaryngologypt_PT
oaire.citation.volume46pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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