Borderline CD30+ Cutaneous Lymphoproliferative Disorder: Report of a Case with Expression of Cytotoxic Markers and Response to Clarithromycin

Ponte, P; Serrão, V; Viana, I; Vale, E; João, A; Cerroni, L

http://hdl.handle.net/10400.17/1006

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Abstract(s)

CD30+ cutaneous lymphoproliferative disorders (CLPDs) are usually characterized by a benign clinical course. The prognostic value of cytotoxic markers in these lymphomas has not been evaluated in large series. We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may have hastened the remission process.

Keywords

Anti-Inflamatórios Antigénio CD30 Claritromicina Linfoma Cutâneo de Células T Neoplasias da Pele Marcadores Biológicos de Tumor

URI

http://hdl.handle.net/10400.17/1006

Citation

J Cutan Pathol. 2011 Mar;38(3):301-5

Publisher

John Wiley & Sons

Collections

DER - Artigos

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