Publication
Borderline CD30+ Cutaneous Lymphoproliferative Disorder: Report of a Case with Expression of Cytotoxic Markers and Response to Clarithromycin
| dc.contributor.author | Ponte, P | |
| dc.contributor.author | Serrão, V | |
| dc.contributor.author | Viana, I | |
| dc.contributor.author | Vale, E | |
| dc.contributor.author | João, A | |
| dc.contributor.author | Cerroni, L | |
| dc.date.accessioned | 2013-02-01T10:38:52Z | |
| dc.date.available | 2013-02-01T10:38:52Z | |
| dc.date.issued | 2011 | |
| dc.description.abstract | CD30+ cutaneous lymphoproliferative disorders (CLPDs) are usually characterized by a benign clinical course. The prognostic value of cytotoxic markers in these lymphomas has not been evaluated in large series. We describe a case of borderline CD30+ CLPD with cytotoxic phenotype, presenting in a 22-year-old male patient as an ulcer on the forearm. He reported having had similar ulcers on the buttock and thigh that spontaneously regressed over the course of 1 year. The lesion resolved with a single course of clarithromycin; a subsequent lesion, too, responded to clarithromycin, and no recurrences or systemic involvement have been documented in the 9-month follow-up. A conservative approach in the management of CD30+ CLPD is recommended. We believe that the anti-inflammatory and apoptotic effects of clarithromycin on T cells may have hastened the remission process. | por |
| dc.identifier.citation | J Cutan Pathol. 2011 Mar;38(3):301-5 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/1006 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | John Wiley & Sons | por |
| dc.subject | Anti-Inflamatórios | por |
| dc.subject | Antigénio CD30 | por |
| dc.subject | Claritromicina | por |
| dc.subject | Linfoma Cutâneo de Células T | por |
| dc.subject | Neoplasias da Pele | por |
| dc.subject | Marcadores Biológicos de Tumor | por |
| dc.title | Borderline CD30+ Cutaneous Lymphoproliferative Disorder: Report of a Case with Expression of Cytotoxic Markers and Response to Clarithromycin | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 305 | por |
| oaire.citation.startPage | 301 | por |
| oaire.citation.title | Journal of Cutaneous Pathology | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |