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Invasive Bacterial Infections in Children With Sickle Cell Disease: 2014–2019

2023Journal article Open access
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dc.contributor.authorGaschignard, J
dc.contributor.authorKoehl, B
dc.contributor.authorRees, DC
dc.contributor.authorRincón-López, E
dc.contributor.authorVanderfaeillie, A
dc.contributor.authorPascault, A
dc.contributor.authorAllali, S
dc.contributor.authorCela, E
dc.contributor.authorOdièvre, MH
dc.contributor.authorHau, I
dc.contributor.authorOliveira, M
dc.contributor.authorGuillaumat, C
dc.contributor.authorBrousse, V
dc.contributor.authorde Montalembert, M
dc.contributor.authorNavarro Gómez, ML
dc.contributor.authorBeldjoudi, N
dc.contributor.authorBardon-Cancho, EJ
dc.contributor.authorEpalza, C
dc.contributor.authorBenkerrou, M
dc.contributor.authorGaschignard, J
dc.contributor.authorKoehl, B
dc.contributor.authorPascault, A
dc.contributor.authorBrousse, V
dc.contributor.authorAllali, S
dc.contributor.authorde Montalembert, M
dc.contributor.authorOdièvre, MH
dc.contributor.authorHau, I
dc.contributor.authorGuillaumat, C
dc.contributor.authorBlais, S
dc.contributor.authorRunel-Belliard, C
dc.contributor.authorPellegrino, B
dc.contributor.authorMalric, A
dc.contributor.authorGuitton, C
dc.contributor.authorGouraud, F
dc.contributor.authorPetras, M
dc.contributor.authorBensaid, P
dc.contributor.authorBasmaci, R
dc.contributor.authorEyssette-Guereau, S
dc.contributor.authorPham, LL
dc.contributor.authorBardon-Cancho, EJ
dc.contributor.authorCela, E
dc.contributor.authorGómez, ML
dc.contributor.authorRincon-Lopez, E
dc.contributor.authorRuiz-Llobet, A
dc.contributor.authorAdan, R
dc.contributor.authorPuyo, PV
dc.contributor.authorRecasens, V
dc.contributor.authorEpalza, C
dc.contributor.authorPerez-Alonso, V
dc.contributor.authorTorrent, M
dc.contributor.authorGomez, AB
dc.contributor.authorVázquez, A
dc.contributor.authorRodríguez, RP
dc.contributor.authorAlfaridi, H
dc.contributor.authorAlmaghrabi, R
dc.contributor.authorHoyoux, M
dc.contributor.authorVanderfaeillie, A
dc.contributor.authorFerreira, T
dc.contributor.authorRees, D
dc.date.accessioned2024-02-27T11:09:26Z
dc.date.available2024-02-27T11:09:26Z
dc.date.issued2023
dc.description.abstractBackground: Children with sickle cell disease (SCD) are at a high risk of invasive bacterial infections (IBI). Universal penicillin prophylaxis and vaccination, especially against Streptococcus pneumoniae, have deeply changed its epidemiology. Analysis of IBI in children with SCD in a post-13-valent pneumococcal vaccine era is limited. Methods: Twenty-eight pediatric hospitals from 5 European countries retrospectively collected IBI episodes in SCD children aged 1 month to 18 years between 2014 and 2019. IBI was defined as a positive bacterial culture or polymerase chain reaction from a normally sterile fluid: blood, cerebrospinal, joint, or pleural fluid and deep surgical specimen. Results: We recorded 169 IBI episodes. Salmonella spp. was the main isolated bacteria (n = 44, 26%), followed by Streptococcus pneumonia (Sp; n = 31, 18%) and Staphylococcus aureus (n = 20, 12%). Salmonella prevailed in osteoarticular infections and in primary bacteremia (45% and 23% of episodes, respectively) and Sp in meningitis and acute chest syndrome (88% and 50%, respectively). All Sp IBI occurred in children ≤10 years old, including 35% in children 5 to 10 years old. Twenty-seven (17%) children had complications of infection and 3 died: 2 because of Sp, and 1 because of Salmonella. The main risk factors for a severe IBI were a previous IBI and pneumococcal infection (17 Sp/51 cases). Conclusions: In a post-13-valent pneumococcal vaccine era, Salmonella was the leading cause of bacteremia in IBI in children with SCD in Europe. Sp came second, was isolated in children ≤10 years old, and was more likely to cause severe and fatal cases.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPediatrics . 2023 Oct 1;152(4):e2022061061pt_PT
dc.identifier.doi10.1542/peds.2022-061061pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4817
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Academy of Pediatricspt_PT
dc.subjectSickle Cell Diseasept_PT
dc.subjectInvasive Bacterial Infectionspt_PT
dc.subjectChildpt_PT
dc.subjectHDE HEM PEDpt_PT
dc.titleInvasive Bacterial Infections in Children With Sickle Cell Disease: 2014–2019pt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue4pt_PT
oaire.citation.startPagee2022061061pt_PT
oaire.citation.titlePediatricspt_PT
oaire.citation.volume152pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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