Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study

Marques da Silva, P; Aguiar, C; Morais, J; DISGEN-LIPID study Investigators

http://hdl.handle.net/10400.17/3857

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Authors

Marques da Silva, P

Aguiar, C

Morais, J

DISGEN-LIPID study Investigators

Abstract(s)

Introduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal. Hypercholesterolemia has a causal role in atherosclerotic CVD. Guidelines recommend that cardiovascular (CV) risk reduction should be individualized and treatment goals identified. Low-density lipoprotein cholesterol (LDL-C) is the primary treatment target. Methods: DISGEN-LIPID was a cross-sectional observational study conducted in 24 centers in Portugal in dyslipidemic patients aged ≥40 years, on lipid-lowering therapy (LLT) for at least three months and with an available lipid profile in the previous six months. Results: A total of 368 patients were analyzed: 48.9% men and 51.1% women (93.9% postmenopausal), of whom 73% had a SCORE of high or very high CV risk. One quarter had a family history of premature CVD; 31% had diabetes; 26% coronary heart disease; 9.5% cerebrovascular disease; and 4.1% peripheral arterial disease. Mean baseline lipid values were total cholesterol (TC) 189 mg/dl, LDL-C 116 mg/dl, high-density lipoprotein cholesterol (HDL-C) 53.5 mg/dl, and triglycerides (TG) 135 mg/dl. Women had higher TC (p<0.001), LDL-C (non-significant) and HDL-C (p<0.001), and lower TG (p=0.002); 57% of men and 63% of women had LDL-C>100 mg/dl (p=0.28), and 58% of men and 47% of women had LDL-C>70 mg/dl (p=0.933). Conclusion: These observational data show that, despite their high-risk profile, more than half of patients under LLT, both men and women, did not achieve the recommended target levels for LDL-C, and a large proportion also had abnormal HDL-C and/or TG. This is a renewed opportunity to improve clinical practice in CV prevention.

Keywords

HSM MED Adult Aged Female Male Biomarkers / blood Cardiovascular Diseases / epidemiology Cardiovascular Diseases / etiology Cardiovascular Diseases / prevention & control Cross-Sectional Studies Dyslipidemias / blood Dyslipidemias / complications Dyslipidemias / drug therapy Humans Hypolipidemic Agents / therapeutic use Lipids / blood Middle Aged Morbidity / trends Portugal / epidemiology Registries Retrospective Studies Survival Rate / trends