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Suboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Study

2019Journal article Open access
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dc.contributor.authorMarques da Silva, P
dc.contributor.authorAguiar, C
dc.contributor.authorMorais, J
dc.contributor.authorDISGEN-LIPID study Investigators
dc.date.accessioned2021-09-28T15:17:53Z
dc.date.available2021-09-28T15:17:53Z
dc.date.issued2019
dc.description.abstractIntroduction: Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in Portugal. Hypercholesterolemia has a causal role in atherosclerotic CVD. Guidelines recommend that cardiovascular (CV) risk reduction should be individualized and treatment goals identified. Low-density lipoprotein cholesterol (LDL-C) is the primary treatment target. Methods: DISGEN-LIPID was a cross-sectional observational study conducted in 24 centers in Portugal in dyslipidemic patients aged ≥40 years, on lipid-lowering therapy (LLT) for at least three months and with an available lipid profile in the previous six months. Results: A total of 368 patients were analyzed: 48.9% men and 51.1% women (93.9% postmenopausal), of whom 73% had a SCORE of high or very high CV risk. One quarter had a family history of premature CVD; 31% had diabetes; 26% coronary heart disease; 9.5% cerebrovascular disease; and 4.1% peripheral arterial disease. Mean baseline lipid values were total cholesterol (TC) 189 mg/dl, LDL-C 116 mg/dl, high-density lipoprotein cholesterol (HDL-C) 53.5 mg/dl, and triglycerides (TG) 135 mg/dl. Women had higher TC (p<0.001), LDL-C (non-significant) and HDL-C (p<0.001), and lower TG (p=0.002); 57% of men and 63% of women had LDL-C>100 mg/dl (p=0.28), and 58% of men and 47% of women had LDL-C>70 mg/dl (p=0.933). Conclusion: These observational data show that, despite their high-risk profile, more than half of patients under LLT, both men and women, did not achieve the recommended target levels for LDL-C, and a large proportion also had abnormal HDL-C and/or TG. This is a renewed opportunity to improve clinical practice in CV prevention.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRev Port Cardiol (Engl Ed). 2019 Aug;38(8):559-569.pt_PT
dc.identifier.doi10.1016/j.repc.2019.02.009. Ept_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/3857
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevier Españapt_PT
dc.subjectHSM MEDpt_PT
dc.subjectAdultpt_PT
dc.subjectAgedpt_PT
dc.subjectFemalept_PT
dc.subjectMalept_PT
dc.subjectBiomarkers / bloodpt_PT
dc.subjectCardiovascular Diseases / epidemiologypt_PT
dc.subjectCardiovascular Diseases / etiologypt_PT
dc.subjectCardiovascular Diseases / prevention & controlpt_PT
dc.subjectCross-Sectional Studiespt_PT
dc.subjectDyslipidemias / bloodpt_PT
dc.subjectDyslipidemias / complicationspt_PT
dc.subjectDyslipidemias / drug therapypt_PT
dc.subjectHumanspt_PT
dc.subjectHypolipidemic Agents / therapeutic usept_PT
dc.subjectLipids / bloodpt_PT
dc.subjectMiddle Agedpt_PT
dc.subjectMorbidity / trendspt_PT
dc.subjectPortugal / epidemiologypt_PT
dc.subjectRegistriespt_PT
dc.subjectRetrospective Studiespt_PT
dc.subjectSurvival Rate / trendspt_PT
dc.titleSuboptimal Lipid Levels in Clinical Practice Among Portuguese Adults With Dyslipidemia Under Lipid-Lowering Therapy: Data From the DISGEN-LIPID Studypt_PT
dc.title.alternativeAlterações Persistentes do Perfil Lipídico na Prática Clínica nos Doentes Adultos Portugueses com Dislipidemia em Tratamento com Antidislipidémicos. Dados do Estudo DISGEN-LIPIDpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage569pt_PT
oaire.citation.startPage559pt_PT
oaire.citation.titleRevista Portuguesa de Cardiologiapt_PT
oaire.citation.volume38pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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